骨骼肌细胞骨架与被动刚度

Skeletal muscle cytoskeleton and passive stiffness

骨骼肌细胞骨架按位置可分为细胞核骨架蛋白、细胞质骨架蛋白、细胞膜骨架蛋白和细胞外基质,实现维持细胞核内和细胞膜内稳态、力传导和机械信号转导等功能。近期研究表明骨骼肌细胞骨架蛋白的损伤或缺失大多都伴随被动刚度(passive stiffness, PS)的变化,影响骨骼肌工作能力。该文梳理了骨骼肌细胞骨架蛋白的结构和功能联系及其对PS的影响,这将有助于进一步理解骨骼肌结构与被动性能的关系,开发新策略改善PS,增强骨骼肌功能,并为肌营养不良症等肌病提供新的治疗思路。

Skeletal muscle cytoskeleton by position can be divided into nuclear skeleton protein,cytoplasmic skeleton protein,cell membrane skeleton protein and extracellular matrix,maintaining the nucleus and cell membrane homeostasis,force conduction and mechanical signal transduction.Recent studies have shown that damage or loss of skeletal muscle cytoskeletal proteins are mostly accompanied by changes in passive stiffness(PS),affecting skeletal muscle working ability.This article reviews the structural and functional links of skeletal muscle cytoskeleton proteins and their effects on PS,which will help to further understand the relationship between skeletal muscle structure and passive performance,develop new strategies to improve PS,enhance skeletal muscle function,and provide new treatment ideas for myopathies such as muscular dystrophy.