匹伐他汀与阿托伐他汀对PCI术后急性心肌梗死患者血脂、血管内皮功能、炎性因子的影响

Therapeutic effects of pitavastatin and atorvastatin on acute myocardial infarction after PCI and its effects on blood lipids,vascular endothelial function and inflammatory factors of patients

目的观察匹伐他汀对PCI术后急性心肌梗死患者血脂、血管内皮功能、炎性因子的影响。方法将84例急性心肌梗死PCI术后患者随机分为2组,观察组术后予匹伐他汀治疗,对照组术后予阿托伐他汀治疗。比较2组治疗前后心功能[左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)]、血管内皮功能及炎性因子[内皮素-1(ET-1)、一氧化氮(NO)水平及炎性因子白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、超敏C-反应蛋白(hs-CRP)]、血脂指标(TG、TC、LDL-C、HDL-C)水平变化及临床疗效,随访6个月,比较2组心血管不良事件及狭窄发生率。结果治疗后观察组总有效率(92.86%)略高于对照组(88.10%),但差异无统计学意义(P>0.05)。术后1个月,观察组心功能指标LVEF、LVEDD、LVESD,炎性因子指标IL-6、TNF-α、hs-CRP,血管内皮功能指标ET-1、NO改善优于对照组(P<0.05),术后3个月血脂TG、TC、LDL-C、HDL-C水平改善优于对照组(P<0.05)。术后6个月,观察组不良心脏事件及狭窄发生率低于对照组(P<0.05)。结论匹伐他汀对PCI术后急性心肌梗患者的疗效确切,能有效改善患者血脂、血管内皮功能、炎性因子,提高患者心功能。

Objective To investigate the therapeutic effects of pitavastatin and atorvastatin on acute myocardial infarction(AMI)after PCI and its effects on blood lipids,vascular endothelial function and inflammatory factors of patients.Methods A total of 84 patients with AMI who underwent PCI were randomly divided into two groups,with 42 cases in each group.The patients in observation group were treated by pitavastatin after surgery,however,those in control group were treated by atorvastatin after surgery.The cardiac function[left ventricular end systolic diameter(LVESD),left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD)],vascular endothelial function and inflammatory factors[endothelin-1(ET-1)Nitric oxide(NO)levels and inflammatory factors interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α),high-sensitivity C-reactive protein(hs-CRP)],blood lipid index(TG,TC,LDL-C,HDL-C)and clinical efficacy were observed and compared between the two groups.Moreover the patients in both groups were followed up for 6 months,and the incidence rates of adverse cardiovascular events and stenosis were observed and compared between the two groups.Results After treatment,the total effective rate(92.86%)in observation group was higher than that(88.10%)in control group,but there was no significant difference(P>0.05).After 1-month treatment,the cardiac function indexes including LVEF,LVEDD,LVESD,inflammatory factors indexes including IL-6,TNF-α,hs-CRP,and vascular endothelial function indexes including ET-1 and NO in observation group were superior to those in control group(P<0.05).After 3-month treatment,the levels of TG,TC,LDL-C,HDL-C in observation group were superior to those in control group(P<0.05).After 6-month treatment,the incidence rates of adverse cardiovascular events and stenosis in observation group were significantly lower than those in control group(P<0.05).Conclusion Pitavastatin has a definite curative effects on AMI after PCI,which can effectively improve the blood lipids,vascular endothelial function,inflammatory factors and cardiac function of patients.