运动干预对食管癌术后辅助化疗患者癌因性疲乏及生命质量的影响

Effect of exercise intervention on cancer-related fatigue and quality of life in patients with postoperative adjuvant chemotherapy for esophageal cancer

目的探讨有氧运动结合抗阻运动对食管癌术后辅助化疗患者癌因性疲乏及生命质量的影响。方法选取2017年1月至2019年6月于福建省肿瘤医院食管癌术后行辅助化疗的86例患者作为研究对象,按照随机数字表法分为研究组与对照组,各43例。对照组给予常规护理,研究组在对照组基础上给予有氧运动结合抗阻运动干预。比较两组化疗前及干预12周后的癌因性疲乏和生命质量。结果干预前,两组情感、行为/严重性、感知、认知/情绪评分及总分比较差异无统计学意义;干预12周后,两组情感、行为/严重性、感知、认知/情绪评分及总分均高于干预前,但研究组低于对照组,差异有统计学意义(P<0.05)。干预前,两组生理状况、社交/家庭状况、情绪状态、功能状况评分比较差异无统计学意义;干预12周后,两组生理状况、社交/家庭状况、情绪状态、功能状况评分均低于干预前,但研究组高于对照组,差异有统计学意义(P<0.05)。结论有氧运动结合抗阻运动可有效减轻食管癌术后辅助化疗患者癌因性疲乏,提高患者生命质量,值得临床推广应用。

Objective To investigate the effect of aerobic exercise combined with anti-group exercise on cancer-related fatigue and quality of life in patients with postoperative adjuvant chemotherapy for esophageal cancer.Methods 86 patients received adjuvant chemotherapy after esophageal cancer surgery in Fujian Cancer Hospital from January 2017 to June 2019 were selected as the research subjects,and they were divided into the study group and the control group according to the random number table method,with 43 cases in each group.The control group was gaved routine nursing,tigue and quality of life before chemotherapy and 12 weeks after intervention were compared between two groups.Results Before intervention,there were no significant differences in the scores of emotion,behavior/severity,perception,cognition/emotion and total scores between the two groups;after 12 weeks of intervention,the score of emotion,behavior/severity,perception,cognition/emotion and total score of the two groups were higher than those before intervention,but the study group was lower than the control group,the differences were statistically significant(P<0.05).Before intervention,there were no significant differences in the scores of physiological status,social/family status,emotional state and functional status between the two groups;after 12 weeks of intervention,the scores of physiological status,social/family status,emotional state and functional status of two groups were lower than those before intervention,but the study group were higher than the control group,the differences were statistically significant(P<0.05).Conclusion Aerobic exercise combined with resistance exercise can effectively reduce cancer-related fatigue and improve the quality of life in patients with postoperative adjuvant chemotherapy of esophageal cancer,which is worthy of clinical promotion and application.