多联疗法治疗非动脉炎性前部缺血性视神经病变的临床疗效

Clinical efficacy of polytherapy in the treatment of nonarteriotic anterior ischemic optic neuropathy

目的探讨多联疗法治疗非动脉炎性前部缺血性视神经病变的临床疗效。方法选取2018年1月至2021年1月本院收治的72例非动脉炎性前部缺血性视神经病变患者作为研究对象,采取随机数字表法分为对照组与实验组,每组36例,对照组采取常规治疗,实验组采取多联疗法治疗,比较两组治疗前后相关指标及临床疗效。结果实验组治疗总有效率为97.22%,高于对照组的66.67%,差异有统计学意义(P<0.05)。治疗后,实验组最佳矫正视力(BCVA)、视野平均敏感度(MS)及对照组BCVA均高于治疗前,实验组视野平均缺损(MD)、视网膜神经纤维层厚度(RNFL)及对照组RNFL均低于治疗前,且实验组BCVA、MS均高于对照组,MD、RNFL均低于对照组,差异有统计学意义(P<0.05)。结论多联疗法治疗非动脉炎性前部缺血性视神经病变疗效确切,能改善患者视力,值得临床推广应用。

Objective To investigate the clinical efficacy of polytherapy in the treatment of nonarteritic anterior ischemic optic neuropathy.Methods A total of 72 patients with nonarteriotic anterior ischemic optic neuropathy admitted to our hospital from January 2018 to January 2021 were selected as the study subjects,and they were divided into the control group and the experimental group by random number table method,with 36 cases in each group.The control group received conventional treatment and the experimental group received polytherapy,the relevant indexes before and after treatment and clinical efficacy were compared between the two groups.Results The total effective rate in the experimental group was 97.22%,which was higher than 66.67%in the the control group,the difference was statistically significant(P<0.05).After treatment,best corrected visualacuity(BCVA),mean sensitivity(MS)in the experimental group and BCVA in the control group were higher than before treatment,MD,RNFL in the experimental group and RNFL in the control group were lower than before treatment,mean defect(MD)and retinal nerve fiber layer thickness(RNFL)in the experimental group were higher than the control group,MD,RNFL were lower than the control group,the differences were statistically significant(P<0.05).Conclusion Polytherapy in the treatment of non-arteriotic anterior ischemic optic neuropathy is effective and can improve the visual acuity of patients,and is worthy of clinical promotion and application.