胃镜下氩离子凝固术对胃息肉患者血清学指标的影响及安全性分析

Effect and Safety Analysis of Argon Ion Coagulation Under Gastroscope on Serological Indexes of Patients with Gastric Polyp

目的:探讨胃镜下氩离子凝固术对胃息肉患者血清学指标的影响。方法:选择2020年1月~2022年12月70例胃息肉患者,以随机数字表法为分组原则将患者分为两组,对照组35例接受高频电切术进行治疗,观察组35例接受胃镜下氩离子凝固术治疗,术后均用药并观察14d。比较两组术后疗效,术前及术后血清白介素-1β(IL-1β)、白介素-6(IL-6)、去甲肾上腺素(E)、皮质醇(Cor)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、血清胃泌素-17(G-17)水平,并计算胃蛋白酶原比值(PGR),及观察期间的不良反应发生情况。结果:与对照组相比,观察组患者的治疗总有效率更高,不良反应发生率更低;与术前相比较,术后两组患者血清IL-1β、IL-6、E、Cor水平均呈现降低趋势,且观察组低于对照组;与术前相比较,两组患者血清PGⅠ、G-17、PGR水平均呈现升高趋势,且观察组更高,差异有统计学意义(P<0.05);两组PGⅡ水平经比较,差异无统计学意义(P>0.05)。结论:胃镜下氩离子凝固术可以提高胃息肉患者的临床治疗效果,减轻机体创伤,降低炎症反应,有助于缓解胃黏膜萎缩症状,修复受损黏膜,且安全性更高。

Objective:To investigate the effect of argon ion coagulation under gastroscopy on serological indexes of patients with gastric polyp.Methods:A total of 70 patients with gastric polyps were included in this study.Sample selection was completed from January 2020 to December 2022.Patients were divided into two groups based on the random number table method.One group of 35 patients received high-frequency electrotomy and was named the control group.The other group of 35 patients was treated by argon ion coagulation under gastroscope and was named as the observation group.All patients were given medication after surgery and observed for 14 days.The postoperative efficacy,and the levels of serum interleukin-1β(IL-1β),interleukin-6(IL-6),norepinephrine(E),cortisol(Cor),pepsinogen I(PG I),pepsinogen II(PG II),and serum gastrin-17(G-17)before and after operation,pepsinogen ratio(PGR)and the occurrence of adverse reactions during the observation period of the two groups were compared.Results:Compared with the control group,the observation group had a higher overall treatment efficiency and a lower incidence of adverse reactions;Compared with preoperative,the levels of serum IL-1β,IL-6,E and Cor in both groups of patients after surgery showed a decreasing trend,and the observation group was lower than the control group;Compared with before surgery,the serum levels of PGⅠ,G-17,and PGR in both groups of patients showed an upward trend,and the observation group had a higher level,with a statistically significant difference(P<0.05);There was no statistically significant difference in PG II levels between the two groups(P>0.05).Conclusion:Argon ion coagulation under gastroscope can improve the clinical treatment effect of patients with gastric polyps,reduce body trauma,reduce inflammation,alleviate the symptoms of gastric mucosa atrophy,repair the damaged mucosa,and is safer.