精神分裂症患者KCNH2和CACNA1C基因多态性及其与认知功能的相关性

Relationship between KCNH2 and CACNA1C gene polymorphisms and cognitive function in patients with schizophrenia

目的探讨精神分裂症患者KCNH2和CACNA1C基因多态性及其与认知功能之间的关系。方法选取2017年6月—2021年6月海南省安宁医院精神分裂症缓解期患者210例(研究组)和健康志愿者210例(对照组)。检测所有研究对象CACNA1C rs1006737、KCNH2 rs3800779基因多态性。采用蒙特利尔认知评估量表(MoCA)评估研究组认知功能,评定患者事件相关电位(ERP),记录失匹配负波(MMN)、P300潜伏期和波幅。比较CACNA1C rs1006737、KCNH2 rs3800779不同基因型患者的MoCA评分,以及MMN的潜伏期、波幅和P300的潜伏期和波幅差异。结果与对照组相比,研究组KCNH2 rs3800779位点TT基因型分布频率降低(P<0.05),TG基因型分布频率升高(P<0.05),T等位基因分布频率降低(P<0.05),G等位基因分布频率升高(P<0.05);CACNA1C rs1006737位点AG基因型分布频率升高(P<0.05),GG基因型分布频率降低(P<0.05),A等位基因分布频率升高(P<0.05),G等位基因分布频率降低(P<0.05)。与KCNH2rs3800779位点GG基因型患者比较,TT、TG基因型患者MoCA评分均降低(P<0.05),MMN和P300潜伏期均较长、波幅均较小(P<0.05)。与CACNA1Crs1006737位点GG基因型患者比较,AA、AG基因型患者MoCA评分均降低(P<0.05),MMN和P300潜伏期均较长、波幅均较小(P<0.05)。结论KCNH2和CACNA1C基因多态性对精神分裂症患者的认知功能有一定的影响。

Objective To investigate the relationship between KCNH2 and CACNA1C gene polymorphisms and cognitive function in patients with schizophrenia.Methods Totally,210 patients with schizophrenia in remission in Anning Hospital from June 2017 to June 2021 were enrolled as study group.Totally,210 healthy volunteers in the same period were enrolled as control group.CACNA1C rs1006737 and KCNH2 rs38007792 gene polymorphisms were determined.The Montreal cognitive assessment(MoCA)was used.The event-related potential(ERP),the latency and amplitude of mismatch negativity(MMN)and P300 were evaluated.MoCA score,MMN,P300 latency and amplitude of patients with different genotypes were compared.Results Compared with control group,instudy group,the distribution frequency of TT genotype at KCNH2 rs3800779 locus was decreased(P<0.05),the distribution frequency of TG genotype was increased(P<0.05),the distribution frequency of T allele was decreased(P<0.05),and the distribution frequency of G allele was increased(P<0.05).The distribution frequency of AG genotype at CACNA1C rs1006737 locus was increased(P<0.05),GG genotype distribution frequency was decreased(P<0.05),A allele distribution frequency was increased(P<0.05),and G allele distribution frequency was decreased(P<0.05).Compared with patients with GG genotype at KCNH2 rs3800779 locus,the patients with TT and TG genotypes had decreased MoCA scores(P<0.05),both MMN and P300 latencies were longer(P<0.05),and amplitudes were smaller(P<0.05).Compared with patients with GG genotype at CACNA1C rs1006737 locus,the patients with AA and AG genotypes had decreased MoCA scores(P<0.05),both MMN and P300 latencies were longer(P<0.05),and amplitudes were smaller(P<0.05).Conclusions KCNH2 and CACNA1C gene polymorphisms affect the cognitive function of patients with schizophrenia.