持留菌形成机制和清除策略研究进展

Research progress on formation mechanism and eradication strategy of bacterial persisters

持留菌虽然很早即被发现,但是在抗感染诊疗中较少被提及。随着抗菌药物耐药和抗药性问题的日益严重,相关研究不断深入。病原菌持留现象已被发现于大多数细菌,并被认为是导致慢性感染和疾病迁延不愈的重要原因。持留菌的形成机制涉及多种细胞生命过程,但具体机制目前尚不明确。近年来,临床针对持留菌的治疗策略已基本形成共识。文章对持留菌形成机制相关研究、临床应对策略进行综述,以期为解决慢性感染性疾病治疗中所面临的重大挑战有所帮助。

Although bacterial persister has been found for a long time,they are rarely mentioned in anti-infective diagnosis and treatment.With the increasingly serious problem of antibiotic resistance and tolerance and the deepening of research,bacterial persistence has been found in most bacteria,and it is considered to be a cause of chronic infection and disease delay.The mechanism of bacterial persister formation involves many cell life processes,but it is still not completely clear.There is a consensus on the treatment strategy for bacterial persisters.This review focuses on the mechanism research of bacterial persisters and the treatment strategies in the recent years,so as to solve the major challenge in the treatment of chronic infectious diseases.