G试验影响因素分析

Analysis on influencing factors of G assay

近年来,免疫抑制和危重患者IFD发生率持续上升。早期诊断IFD对降低患者死亡率、改善预后具有十分重要的意义。G试验是早期诊断侵袭性真菌病(IFD)重要的血清学方法之一,目前已广泛应用于临床。然而,医源性污染、细菌感染、肠道黏膜受损会导致G试验结果假阳性;抗真菌药物治疗、突破性念珠菌感染等会导致G试验结果假阴性。文章对G试验的影响因素进行综述,以帮助临床和实验室正确根据G试验结果及时制定相应的治疗策略。

G assay is one of the most important serological methods for the early diagnosis of invasive fungal disease(IFD).Nowadays it is widely used in clinical practice.However,medical contamination,bacterial infection and intestinal mucosal damage can lead to false positivity of G assay results.The use of antifungal drug and breakthrough Candida infection can lead to false negativity of G assay results.In addition,as the proportion of immunosuppressed and critical patients suffering from IFD continues to increase,early diagnosis of IFD is of importance to reduce mortality and improve the prognosis of those patients.This review focuses on the factors influencing G assay to give proper guidance of the use of G assay both in clinical practice and in laboratory,as well as the corresponding countermeasures.