维生素K环氧化物还原酶复合物亚基1基因多态性与冠心病、脑卒中相关性进展

Progress of association between vitamin K epoxide reductase complex subunit 1 gene polymorphism and coronary heart disease and stroke

维生素K环氧化物还原酶复合物亚基1(VKORC1)通过影响维生素K依赖的凝血因子和非凝血因子的羧化,从而影响血栓的易感性以及大动脉壁的钙化。血栓和动脉硬化直接导致血管性疾病如冠心病、脑卒中。国内外关于VKORC1与冠心病、脑卒中关系的临床研究存在分歧。本文就VKORC1与冠心病、脑卒中关系的研究进展作一综述。

Vitamin K epoxide reductase complex subunit 1(VKORC1)influences the susceptibility to thrombosis and calcification of the aortic wall by influencing the carboxylation of vitamin K-dependent clotting and non-clotting factors.Thrombosis and arteriosclerosis directly lead to vascular diseases such as coronary heart disease and stroke.There are differences in domestic and overseas clinical studies on the relationship between VKORC1 and coronary heart disease and stroke.This article reviews the research progress on the relationship between VKORC1 and coronary heart disease and stroke.