摘要
目的总结丝氨酸苏氨酸酪氨酸激酶1(serine threonine tyrosine kinase 1,STYK1)在肿瘤发生发展中的生物学功能及其分子调控机制。方法检索近年来有关STYK1与肿瘤进展研究的相关文献并进行综述。结果STYK1在多种肿瘤中表达上调并与预后相关,可能通过MEK/ERK、PI3K/AKT、JAK/STAT等信号通路及其靶向蛋白调控肿瘤细胞的增殖、凋亡、迁移、转移、有氧糖酵解、耐药等生物学功能,促进肿瘤的恶性进展。结论STYK1有望成为恶性肿瘤治疗的新靶点,但其调控肿瘤进展的分子机制及其上游调控因子有待进一步挖掘。
Objective To summarize the biological function and molecular regulation mechanism of serine threonine tyrosine kinase 1(STYK1)in tumor occurrence and development.Method The relevant literature about STYK1 and tumor progression in recent years was searched and reviewed.Results The expression of STYK1 was upregulated in a variety of tumors and was related to the prognosis.STYK1 might regulate the proliferation,apoptosis,migration,metastasis,aerobic glycolysis,drug resistance and other biological functions of tumor cells through MEK/ERK,PI3K/AKT,JAK/STAT and their targeting proteins,and promote the malignant progress of tumors.Conclusion STYK1 is expected to become a new target for the treatment of malignant tumors,but the molecular mechanism of its regulation of tumor progression and its upstream regulators need to be further explored.
作者
李俊峰
阮万百
尹艳梅
彭磊
朱克祥
LI Junfeng;RUAN Wanbai;YIN Yanmei;PENG Lei;ZHU Kexiang(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,P.R.China;Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou 730000,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2023年第10期1258-1264,共7页
Chinese Journal of Bases and Clinics In General Surgery
基金
国家自然科学基金资助项目(项目编号:81960516)。
关键词
丝氨酸苏氨酸酪氨酸激酶1
肿瘤进展
生物学功能
耐药
serine threonine tyrosine kinase 1
tumor progression
biological function
drug resistance
