地西泮片和右美托咪定联合用于酒精戒断综合征的疗效观察

Observation on the therapeutic Effect of Combination of Diazepam Tablets and Dexmedetomidine on Alcohol Withdrawal Syndrome

目的 研究地西泮片和右美托咪定联合用于酒精戒断综合征的临床疗效。方法 选择2020年5月至2022年6月驻马店市第二人民医院收治的60例患有酒精戒断综合征的患者作为研究对象,并随机分为两组。对照组患者(n=30)采用地西泮片治疗;研究组患者(n=30)采用地西泮片和右美托咪定联合治疗。对治疗后两组患者的疗效、镇静效果、不良反应和对酒精的渴望程度进行比较。结果 治疗后研究组的治疗有效率为96.67%,与对照组的治疗有效率76.67%相比,差异有统计学意义(P<0.05);研究组的HAMD与HAMA的分数显著低于对照组,差异有统计学意义(P<0.05);研究组患者治疗后不良反应的发生率(6.67%)显著低于对照组(30.00%),差异有统计学意义(P<0.05);经过1 d以及7 d的治疗后,研究组患者对酒精的渴望程度显著低于对照组,差异有统计学意义(P<0.05)。结论 地西泮片和右美托咪定联合用于酒精戒断综合征治疗的临床疗效显著,对患者的镇静效果良好,显著降低了患者的不良反应发生率以及对酒精的渴望程度。

Objective To study the clinical efficacy of diazepam tablets combined with dexmedetomidine in the treatment of alcohol withdrawal syndrome.Methods A total of Sixty patients with alcohol withdrawal syndrome admitted to the Second People's Hospital of Zhumadian City from May 2020 to June 2022 were selected as the study subjects and randomly divided into two groups.The control group patients(n=30) were treated with diazepam tablets;The study group patients(n=30) were treated with a combination of diazepam tablets and dexmedetomidine.the efficacy,sedative effect,adverse reactions,and craving for alcohol between the two groups of patients after treatment were compared.Results After treatment,the effective rate of the study group was 96.67%,which was statistically significant(P<0.05) compared to the control group's effective rate of 76.67%;The scores of HAMD and HAMA in the study group were significantly lower than those in the control group,with a statistically significant difference(P<0.05);The incidence of adverse reactions after treatment in the study group(6.67%) was significantly lower than that in the control group(30.00%),with a statistically significant difference(P<0.05);After 1 and 7 days of treatment,the desire for alcohol in the study group was significantly lower than that in the control group,with a statistically significant difference(P<0.05).Conclusion The combination of diazepam tablets and dexmedetomidine has a significant clinical efficacy in the treatment of alcohol withdrawal syndrome,with good sedative effect on patients,significantly reducing the incidence of adverse reactions and the degree of alcohol craving.