乳酸菌阴道胶囊对念珠菌性阴道炎妊娠患者炎性细胞因子与分娩结局的影响

Impacts of Lacidophilin Vaginal Capsules on the Inflammatory Cytokines and Delivery Outcomes for Candidal Vaginitis Pregnant Women

目的 分析乳酸菌阴道胶囊用于念珠菌性阴道炎(CV)妊娠患者对其炎性细胞因子和分娩结局的影响。方法 选取2021年1月至2022年5月滑县人民医院收治的CV妊娠患者共60例进行研究,经随机数表法将其中30例归为对照组(克霉唑治疗),余下30例归为观察组(于前组基础上加以乳酸菌阴道胶囊)。观察两组的临床疗效;治疗前后阴道分泌物酸碱度值(pH)≤4.5、优势菌群是乳杆菌、菌群密度Ⅱ~Ⅲ级比例;治疗前后血清中白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)及肿瘤坏死因子-α(TNF-α)含量;分娩结局;不良反应情况。结果 观察组有效率(96.67%)较对照组(80.00%)高,差异有统计学意义(P<0.05)。治疗前,两组阴道分泌物pH≤4.5、优势菌群是乳杆菌、菌群密度Ⅱ~Ⅲ级比例相比,差异无统计学意义(P> 0.05);治疗后,观察组阴道分泌物pH≤4.5、优势菌群是乳杆菌、菌群密度Ⅱ~Ⅲ级比例较对照组高,差异有统计学意义(P<0.05)。治疗前,两组血清IL-2、IL-6、CRP、TNF-α水平相比,差异无统计学意义(P> 0.05);治疗后,观察组血清IL-2、IL-6、CRP、TNF-α水平均较对照组低,差异有统计学意义(P<0.05)。观察组早产、胎膜早破、产褥感染、新生儿黄疸以及低体重儿出现比例较对照组低,差异有统计学意义(P<0.05)。两组头晕头痛、腹痛以及皮肤瘙痒不良反应相比,差异无统计学意义(P> 0.05)。结论 乳酸菌阴道胶囊用于CV妊娠患者疗效理想,能减少其炎性细胞因子分泌,改善其分娩结局和阴道微生态,且安全性较高,值得采用。

Objective To analyze the impacts of lacidophilin vaginal capsules on the inflammatory cytokines and delivery outcomes for candidal vaginitis(CV)pregnant women.Methods A total of 60 CV pregnant women treated from January 2021 to May 2022 in Huaxian People's hospital were investigated.According to random number table,30 cases were assigned to the control group(treated with clotrimazole),and the remaining 30 cases were assigned to the observation group(supplemented with lactobacillus vaginal capsules on the basis of the previous group).Group comparison results were concluded through the clinical effects,vaginal secretion pondus hydrogenii(pH)≤4.5,dominant lactobacillus ratio,class II-III flora density ratios,serum Interleukin-2(IL-2),Interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)contents,delivery outcomes and adverse drug reactions.Results The effective treatment rate in the observation group(96.67%)was higher than control group(80.00%),and the difference was statistically significant(P<0.05);before treatment,there were no significant between-group differences about the vaginal secretion pH≤4.5,dominant lactobacillus ratio and classⅡ~Ⅲflora density ratios(P>0.05);after treatment,the vaginal secretion pH≤4.5,dominant lactobacillus ratio and classⅡ~Ⅲflora density ratios in the observation group were higher than control group,and the difference was statistically significant(P<0.05);before treatment,serum IL-2,IL-6,CRP and TNF-αlevels between groups were not significantly different(P>0.05);after treatment,serum IL-2,IL-6,CRP and TNF-αlevels in the observation group were lower than control group,and the difference was statistically significant(P<0.05);the occurrences of premature delivery,fetal membrane premature rupture,puerperal infections,neonatal jaundice and low-birth weight infants in the observation group were lower than control group,and the difference was statistically significant(P<0.05);there were no significant between-group differences about the adverse reactions like dizziness,headache,stomachache and skin itch(P>0.05).Conclusion Lacidophilin vaginal capsules have ideal therapeutic effects for CV pregnancy patients,can reduce their secretion of inflammatory cytokines,improve their delivery outcomes and vaginal microbiota,and have high safety,making them worth adopting.