黄芪桂枝五物汤颗粒对脑卒中恢复期患者神经功能及偏身感觉障碍的影响

Effects of Huangqi Guizhi Wuwu Decoction Granules on Neurological Function and Hemisensory Disorder in Convalescent Stroke Patients

目的 探究黄芪桂枝五物汤颗粒对脑卒中恢复期患者神经功能及偏身感觉障碍的影响。方法 选择2021年6月至2023年6月收治的95例脑卒中恢复期患者作为研究对象,采用随机数字表法分为常规组(n=47)和研究组(n=48),其中常规组采取常规治疗,研究组在常规治疗的基础上增加黄芪桂枝五物汤颗粒治疗,比较两组神经功能、脑血流相关指标水平、偏身感觉障碍和上下肢运动功能的改善情况及不良反应发生率。结果 治疗后,两组患者美国国立卫生研究院卒中量表(NIHSS)评分均随时间延长而降低,且研究组治疗后7 d、治疗后15 d、治疗后30 d的NIHSS评分均低于常规组,差异有统计学意义(P<0.05)。治疗后,两组脑血流中平均血流速度(Vm)、脉动指数(PI)、阻力指数(RI)水平均优于治疗前,且研究组改善情况优于常规组,差异有统计学意义(P<0.05)。治疗后,两组偏身感觉障碍评分、上下肢运动功能评分均高于治疗前,且研究组高于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率分别为17.02%、12.50%,组间比较差异无统计学意义(P> 0.05)。结论 黄芪桂枝五物汤颗粒对脑卒中恢复期患者神经功能及偏身感觉障碍的恢复有积极作用,且能同时改善上下肢运动功能、维护脑血流循环,并不会增加不良反应,优势明显,应用价值高。

Objective To explore the effect of Huangqi Guizhi Wuwu Decoction granules on neurological function and hemisensory disturbance in patients with stroke recovery period.Methods A total of 95 patients with stroke in recovery stage admitted from June 2021 to June 2023 were selected as the research objects,and they were divided into conventional group(n=47)and study group(n=48)by random number table method.The conventional group was treated with conventional treatment,and the study group was treated with Huangqi Guizhi Wuwu Decoction granules on the basis of conventional treatment.The improvement of neurological function,cerebral blood flow related indicators,hemisensory disturbance,upper and lower limb motor function and the incidence of adverse reactions were compared between the two groups.Results After treatment,the National Institutes of Health Stroke Scale(NIHSS)scores decreased over time in both groups.The NIHSS scores of the study group at 7 d,15 d,and 30 d after treatment were lower than those in the routine group,with significant differences(P<0.05).After treatment,the mean blood flow velocity(Vm),pulsatile index(PI),and resistance index(RI)in cerebral blood flow in the two groups were significantly improved compared with those before treatment,and compared with the conventional group,the improvement in the study group was better,with significant differences(P<0.05).After treatment,the scores of hemiparesis and motor function of upper and lower limbs in both groups were significantly higher than those before treatment,and the research group was higher than the routine group,with significant differences(P<0.05).The incidence of adverse reactions in the two groups was 17.02%and 12.50%,respectively,and there was no statistical significance between the two groups(P>0.05).Conclusion Huangqi Guizhi Wuwu Decoction granules have a positive effect on the recovery of neurological function and hemisensory disturbance in patients with stroke recovery period,and can simultaneously improve the motor function of the upper and lower extremities and maintain the cerebral blood circulation without increasing adverse reactions,with obvious advantages,the application value is high.