甲苯磺酸瑞马唑仑在儿童小肠镜检查麻醉中的应用价值

Application of Remimazolam Toluenesulfonate in Anesthesia for Small Intestinoscopy in Children

【目的】探讨甲苯磺酸瑞马唑仑在儿童小肠镜检查麻醉中的应用价值。【方法】选择2022年4月至2022年12月本院收治的98例在全麻下行小肠镜检查患儿,采用随机数字表法分为丙泊酚组(P组)和甲苯磺酸瑞马唑仑组(R组),每组49例。比较两组麻醉诱导成功率、麻醉维持成功率、患儿意识消失时间;比较两组患儿入室平静时(T_(0))、给药后1 min(T_(1))、给药后2 min(T_(2))、气管插管后(T_(3))、手术结束时(T_(4))、入PACU时(T_(5))的心率(HR)、收缩压(SBP)、舒张压(DBP)、血氧饱和度(SPO_(2));比较两组围术期相关指标、不良反应及术后行为改变情况。【结果】R组镇静起效时间明显长于P组,差异有统计学意义(P<0.05)。T_(1)、T_(2)、T_(3)、T_(4)、T_(5)时,两组患儿HR、SBP、DBP均明显低于T_(0)时(P<0.05);T_(1)、T_(2)、T_(5)时,两组患儿SPO_(2)明显低于T_(0)时(P<0.05)。T_(1)、T_(2)时,R组患儿HR、SBP、DBP、SPO_(2)均高于P组(P<0.05)。R组苏醒时间短于P组,差异有统计学意义(P<0.05)。R组围术期低血压、心动过缓、呼吸抑制和注射痛的发生率低于P组,差异有统计学意义(P<0.05);两组术后PHBQ-AS评分比较,差异无统计学意义(P>0.05)。【结论】甲苯磺酸瑞马唑仑应用于儿童小肠镜检查全身麻醉中安全有效,且不良反应的发生率较低,值得临床借鉴。

【Objective】To explore the clinical effect of remimazolam toluenesulfonate in anesthesia for small intestinal endoscopy in children.【Methods】A total of 98 children who underwent small intestinal endoscopy under general anesthesia and were admitted to our hospital from April 2022 to December 2022 were randomly divided into a propofol group(P group)and a remimazolam toluenesulfonate group(R group)using a random number table method,with 49 cases in each group.We compared the success rates of anesthesia induction,anesthesia maintenance,and the time of consciousness disappearance between the two groups;Compare the heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),and blood oxygen saturation(SPO_(2))of two groups of children at rest(T_(0)),1 minute after administration(T_(1)),2 minutes after administration(T_(2)),after tracheal intubation(T_(3)),at the end of surgery(T_(4)),and at PACU(T_(5));Two groups of perioperative related indicators,adverse reactions,and postoperative behavioral changes were also compared.【Results】The onset time of sedation in the Group R was significantly longer than that in the Group P,with a statistically significant difference(P<0.05).At T_(1),T_(2),T_(3),T_(4),and T_(5),the HR,SBP,and DBP of the two groups of children were significantly lower than those at T_(0)(P<0.05);At T_(1),T_(2),and T_(5),the SPO_(2) of the two groups of children was significantly lower than at T_(0)(P<0.05).At T_(1) and T_(2),the HR,SBP,DBP,and SPO_(2) levels in the Group R were higher than those in the Group P(P<0.05).The awakening time of the Group R was shorter than that of the Group P,and the difference was statistically significant(P<0.05).The incidence of perioperative hypotension,bradycardia,respiratory depression,and injection pain in the Group R was lower than that in the Group P,and the difference was statistically significant(P<0.05);There was no statistically significant difference in postoperative PHBQ-AS scores between the two groups(P>0.05).【Conclusion】Remimazolam toluenesulfonate is safe and effective in general anesthesia for small intestinal endoscopy in children,and the incidence of adverse reactions is low,which is worthy of clinical reference.