肛周脓肿和肛瘘组织及外周血中IL-17的表达及临床意义

Expression and Clinical Significance of IL-17 in Perianal Abscess,Anal Fistula Tissue and Peripheral Blood

【目的】探讨白细胞介素-17(IL-17)在肛周脓肿、肛瘘组织和外周血中的表达及其临床意义。【方法】选取2022年1月至12月本院收治的50例原发性肛周脓肿患者(观察组),根据术后6个月的随访结果将其分为康复组(未复发或出现肛瘘)和肛瘘组(进展为肛瘘)。另外选择同期于本院进行手术治疗的50例混合痔患者(对照组)。根据观察组患者IL-17蛋白阳性表达情况将其分为阳性组和阴性组。记录观察组患者术后随访情况,比较不同组间肛门直肠组织IL-17蛋白表达水平及不同患者IL-17 mRNA表达水平。【结果】观察组IL-17蛋白阳性表达率显著高于对照组,差异有统计学意义(P<0.01)。阳性组脓肿直径≥5 cm、伤口表面愈合时间≥4周、进展为肛瘘所占比例高于阴性组,差异均有统计学意义(P<0.05)。观察组患者IL-17 mRNA表达水平高于对照组,差异有统计学意义(P<0.001)。观察组患者术后随访6个月,肛瘘组患者IL-17 mRNA表达水平高于康复组,差异有统计学意义(P=0.014)。【结论】肛周脓肿、肛瘘患者IL-17蛋白阳性表达率高,IL-17 mRNA表达水平高,IL-17在肛周脓肿及肛瘘的发生、发展中发挥重要作用。

【Objective】To investigate the expression and clinical significance of interleukin-17(IL-17)in tissue and peripheral blood of perianal abscess,anal fistula.【Methods】Select 50 patients with primary perianal abscess admitted to our hospital from January 2022 to December(observation group),and divide them into rehabilitation group(no recurrence or occurrence of anal fistula)and anal fistula group(progression to anal fistula)based on the follow-up results of 6 months after surgery.Select 50 patients with mixed hemorrhoids who underwent surgical treatment in our hospital during the same period(control group).According to the positive expression of IL-17 protein in the observation group,patients were divided into a positive group and a negative group.Record the postoperative follow-up of patients in the observation group,and compare the expression levels of IL-17 protein and IL-17 mRNA in the anal and rectal tissues between different groups.【Results】The positive expression rate of IL-17 protein in the observation group was significantly higher than that in the control group,with a statistically significant difference(P<0.01).The proportion of abscess diameter≥5 cm,wound surface healing time≥4 weeks,and progression to anal fistula in the IL-17 protein positive expression group was higher than that in the IL-17 protein negative expression group;The difference was statistically significant(P<0.05).The expression level of IL-17 mRNA in the observation group was higher than that in the control group with a statistically significant difference(P<0.001).Patients in the observation group were followed up for 6 months after surgery;And the result showed that IL-17 mRNA expression level in the anal fistula group was higher than that in the rehabilitation group with a statistically significant difference(P=0.014).【Conclusion】The positive expression rate of IL-17 protein and the expression level of IL-17 mRNA are high in patients with perianal abscess and anal fistula.IL-17 plays an important role in the occurrence and development of perianal abscess and anal fistula.