血清GFAP、S100B水平与早产儿脑损伤的相关性

Correlation of Serum GFAP and S100B Levels with Brain Damage in Premature Infants

【目的】探讨血清胶质纤维酸性蛋白(GFAP)、S100蛋白B(S100B)水平与早产儿脑损伤的相关性。【方法】选取2019年3月至2021年3月在榆林市第一医院出生的94例早产儿,根据是否发生脑损伤分为发生组(n=38)和未发生组(56例)。比较两组患儿血清GFAP、S100B水平及Apgar评分,比较不同严重程度脑损伤早产儿血清GFAP、S100B水平及Apgar评分。采用Pearson相关性分析脑损伤患儿血清GFAP、S100B水平与出生后5 min Apgar评分的相关性;采用受试者工作特征(ROC)曲线分析出生后12 h血清GFAP、S100B水平评估早产儿脑损伤的价值。【结果】发生组患儿出生后12 h、出生后3 d血清GFAP、S100B水平均高于未发生组(P<0.05),两组患儿出生后3 d血清GFAP、S100B水平均低于出生后12 h(P<0.05),发生组患儿出生后5 min Apgar评分低于未发生组(P<0.05)。重度组血清GFAP、S100B水平高于轻度组和中度组(P<0.05),中度组高于轻度组(P<0.05);重度组患儿出生后5 min Apgar评分低于轻度组和中度组(P<0.05),中度组患儿低于轻度组(P<0.05)。Pearson相关性分析显示,脑损伤患儿出生后12 h、出生后3 d的血清GFAP、S100B水平均与出生后5min Apgar评分呈负相关(均P<0.05)。ROC曲线分析显示,出生后3 d及12 h血清GFAP、S100B水平评估早产儿脑损伤的曲线下面积(AUC)分别为0.848、0.866、0.908、0934(均P<0.05)。【结论】血清GFAP、S100B水平均与早产儿脑损伤有关,可作为评估早产儿脑损伤的敏感指标。

【Objective】To explore levels of serum glial fibrillary acidic protein(GFAP)and S100 protein B(S100B)and their correlation with brain damage in premature infants.【Methods】A total of 94 premature infants who were born in our hospital between March 2019 and March 2021 were selected and they were divided into the occurrence group(n=38 cases)and non-occurring group(n=56 cases)according to whether brain damage occurred.The levels of serum GFAP and S100B plus Apgar scores were compared in both groups.Then,the levels serum GFAP and S100B,and Apgar scores of premature infants with different severity of brain damage were compared.Pearson correlation was used to analyze the correlation of serum GFAP and S100B levels in brain injury children with their Apgar scores at 5 minutes after birth.The receiver operating characteristic(ROC)curve was used to analyze the value of serum GFAP and S100B levels at 12 hours after birth in assessing brain damage in premature infants.【Results】The serum levels of GFAP and S100B at 12 hours and 3 days after birth in the occurrence group were higher than those in the non-occurrence group at 12 hours and 3 days after birth(P<0.05).The serum levels of GFAP and S100B at 3 days after birth in the two groups were lower than that at 12 hours after birth(P<0.05).The Apgar score at 5 minutes after birth in the occurrence group was lower than that in the non-occurrence group(P<0.05).The levels of serum GFAP and S100B in the severe group were higher than those in the mild and moderate groups(P<0.05),while those in the moderate group were higher than those in the mild group(P<0.05);The Apgar score at 5 minutes after birth in the severe group was lower than that in the mild and moderate groups(P<0.05),while the Apgar score in the moderate group was lower than that in the mild group(P<0.05).Pearson correlation analysis showed that serum GFAP and S100B levels in children with brain injury at 12 hours and 3 days after birth were negatively correlated with Apgar score at 5 minutes after birth(all P<0.05).ROC curve analysis showed that the area under the curve(AUC)for assessing brain injury in preterm infants with serum GFAP and S100B levels at 3 and 12 hours after birth were 0.848,0.866,0.908,and 0934,respectively(all P<0.05).【Conclusion】Serum GFAP and S100B levels are related to brain damage in premature infants,which can be used as sensitive indicators to assess brain damage in premature infants.