维生素在酒精性肝病中作用的研究进展

Progress in roles of vitamins in alcoholic liver disease

酒精性肝病(alcoholic liver disease, ALD)是中国常见的肝脏疾病之一^([1])。过度饮酒会损伤肝脏及其功能,进而导致ALD。ALD最初表现为脂肪肝,之后可能逐渐发展为肝炎、肝纤维化和肝硬化,乃至肝癌^([2])。目前,ALD的主要治疗措施是戒酒和营养支持,除对晚期患者实施肝移植外,尚无有效的治疗手段和药物^([3])。因此,临床迫切需要能有效治疗ALD的药物。

Long-term or heavy drinking induces liver damage,and affects the absorption,transformation,uti‐lization and storage of vitamins,leading to vitamin deficiency,which further aggravates liver damage and exacerbates alco‐holic liver disease(ALD).Secondary malnutrition secondary to impaired liver function is a common complication of ALD and is associated with poor quality of life and increased mortality.Providing nutritional support,including vitamins,to ALD patients has been a standard clinical practice for over fifty years.In this review,we provide a brief account on the ef‐fect of alcohol on vitamin status and how the deficiency of vitamins affects the development and prognosis of ALD,with a special focus on vitamins A,C,E,D,and B(B1,B3,B6,B12,and folic acid).At present,vitamin supplementation is mainly used in the setting of ALD to prevent or treat vitamin deficiency and its accompanying complications,while the ap‐plication of higher doses of vitamins is lacking.Recent studies have revealed the regulatory effect of vitamins on the gut-liv‐er axis and the maintenance of muscle mass,providing a theoretical basis for the utilization of vitamins in alleviating ALD.