摘要
In order to make the synthetic route of Thiamidol more efficient and easier to scale up,a new method was developed.The compound 2,4-dihydroxyacetophenone was dissolved in ethyl acetate and brominated with cupric bromide.After bromination,the mixture was filtered to remove cuprous bromide.The obtained ethyl acetate solution containing 2-bromo-1-(2,4-dihydroxyphenyl)ethanone was directly reacted with(2-methylpropanoyl)thiourea to obtain the precipitate of Thiamidol hydrobromide.The precipitate was neutralized by deacidification and recrystallized to afford Thiamidol with high purity.In addition,in the screening of fertility-promoting substances,Thiamidol was found to be effective in protecting human sperm from motility loss in vitro.This suggests that it may have potential application in fertility protection and promotion.
作者
朱柔钰
郭利娜
朱俊
刁华
邵志宇
ZHU Rouyu;GUO Lina;ZHU Jun;DIAO Hua;SHAO Zhiyu(College of Chemistry and Chemical Engineering,Donghua University,Shanghai 201620,China;NHC Key Laboratory of Reproduction Regulation,Shanghai Institute for Biomedical and Pharmaceutical Technologies,Shanghai 200032,China;National Rodent and Leporid Laboratory Animal Resource Center,Shanghai 200031,China)
基金
Development Fund for Shanghai Talents,China(No.15431903000)。
