摘要
转录因子阴阳-1(Yin-Yang1,YY1)是一种复杂的蛋白,通过抑制或激活多种基因表达来调控重要的生命活动,如增殖、分化、衰老和凋亡等。YY1除了作为传统转录因子,还通过调控染色质结构,以及相分离机制等来发挥作用。研究发现YY1在生殖系统起到重要的调控作用且与动物繁殖性能密切相关。文章综述了YY1的作用机制及其在动物繁殖调控方面的作用和潜在机制,以期为今后动物繁殖调控的深入研究提供理论依据。
The transcription factor Yin-Yang1(YY1)is a complex protein that regulates important life activities,such as cell proliferation,differentiation,aging,and apoptosis by inhibiting or activating multiple genes expression.YY1 functions mainly acts as a traditional transcription factor,regulating chromosome structure and phase separation mechanism.It was found that YY1 played an important regulatory role in the reproductive system and was closely related to animal reproductive performance.The article reviews the mechanism of YY1 on gene expression regulation and its role on animal reproductive regulation,which providing a theoretical basis for further research on animal reproductive regulation.
作者
邢文文
齐南南
李梦轩
刘吉英
XING Wenwen;QI Nannan;LI Mengxuan;LIU Jiying(College of Biotechnology,Jiangsu University of Science and Technology,Zhenjiang 212018,China)
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2023年第10期4040-4049,共10页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金(32202674)
江苏省自然科学基金(bk20200994)
江苏省研究生科研与实践创新计划项目(SJCX22_1980)。
关键词
YY1
转录调控
卵巢
精子发生
生殖激素
繁殖调控
YY1
transcriptional regulation
ovary
spermatogenesis
reproductive hormone
reproductive regulation
