血清视黄醇结合蛋白、脂蛋白A、同型半胱氨酸联合检测对冠心病的诊断价值

Diagnostic value of serum retinol binding protein,lipoprotein A and homocysteine combined detection in coronary heart disease

目的探讨血清视黄醇结合蛋白(RBP)、脂蛋白A(LpA)、同型半胱氨酸(Hcy)在冠心病患者病程进展中的变化及三者联合检测对冠心病患者的诊断价值。方法纳入2023年1-6月在昆山市第一人民医院心血管内科明确诊断为冠心病的193例患者作为冠心病组,其中急性心肌梗死患者(AMI组)63例,不稳定性心绞痛患者(UAP组)66例,稳定性心绞痛患者(SAP组)64例。另选取同期65例体检健康者为健康对照组(HC组)。检测并比较冠心病组、HC组,以及不同类型冠心病患者血清RBP、LpA、Hcy水平。结果冠心病组血清RBP、LpA、Hcy水平均高于HC组,差异有统计学意义(P<0.01)。冠心病各组RBP、Hcy、LpA水平由高到低依次为AMI组、UAP组、SAP组、HC组,差异均有统计学意义(P<0.05)。冠心病患者RBP、LpA、和Hcy三者联合检测的阳性率高于三者单独检测,并且冠心病各组RBP、LpA和Hcy三项联合检测的阳性率高于三者单独检测,差异均有统计学意义(P<0.05)。结论血清RBP、LpA、Hcy水平与冠心病密切相关,三者联合检测可提高冠心病诊断的检出率。

Objective To investigate the changes of serum retinol binding protein(RBP),lipoprotein A(LpA)and homocysteine(Hcy)in patients with coronary heart disease and the value of their combined detection in the diagnosis of coronary heart disease.Methods A total of 193 patients diagnosed with coronary heart disease in the cardiovascular department of the First People′s Hospital of Kunshan from January to June 2023 were selected as the coronary heart disease group,including 63 patients with acute myocardial infarction(AMI group),66 patients with unstable angina pectoris(UAP group)and 64 patients with stable angina pectoris(SAP group).Another 65 healthy subjects in the same period were selected as healthy control group(HC group).The serum levels of RBP,LpA and Hcy in coronary heart disease group,HC group and patients with different types of coronary heart disease were detected and compared.Results The serum levels of RBP,LpA and Hcy in coronary heart disease group were higher than those in HC group,the differences were statistically significant(P<0.01).The levels of RBP,Hcy and LpA in coronary heart disease groups were AMI group,UAP group,SAP group and HC group from high to low,and the differences were statistically significant(P<0.05).The positive rate of the combined detection of RBP,LpA and Hcy in coronary heart disease patients was higher than that of the single detection,and the positive rate of the combined detection of RBP,LpA and Hcy in coronary heart disease groups was higher than that of the single detection,with statistical significance(P<0.05).Conclusion Serum RBP,LpA and Hcy levels are closely related to coronary heart disease.The combined detection of RBP,LPA and HCY could improve the positive detection rate of coronary heart disease.