老年衰弱生物标志物研究进展

A review on progress in research on biomarkers of frailty in elderly

衰弱是一种老年人群中常见的、以机体稳态储备能力下降及抗应激能力减退为特征的临床状态,在我国有较高的年发生率且与诸多不良结局相关,给家庭和社会带来沉重负担。因此,对老年衰弱的监测及早期诊断将有助于早期干预措施的实施,从而达到延缓或逆转衰弱的发生,维持老年健康的目的。鉴于衰弱是机体多组织器官功能衰退综合作用的结果,与机体功能水平相关的生物因子或可为衰弱的监测提供新思路。因此,本文将从代谢、免疫、氧化应激、炎症、营养等方面介绍与衰弱相关的生物标志物,以期为衰弱的监测与早期诊断提供更多的生物学依据。

Frailty is a common clinical condition in older adults,which is characterized by decreased steady-state reserve capacity and anti-stress ability.The incidence of frailty is high in China and is associated with many adverse outcomes,bringing heavy burden to the family and society.Therefore,frailty monitoring and early detection will contribute to the implementation of relevant interventions and to delay the onset of frailty or even reverse frailty status and finally to a good maintenance in health condition.Since frailty is the result of multi-organ functional declines,evaluations on biological factors related to body function may provide a new solution for frailty monitoring.In this paper,we summarize the research on frailty-related biomarkers of metabolism,immunity,oxidative stress,inflammation and nutrition for providing a reference to monitoring and early diagnosis of frailty.