蛹油在遗传代谢病治疗中的应用

Bombyx mori oil in the treatment of inherited metabolic disorders

遗传代谢病临床表现复杂,致残及致死率高,缺乏特异性,诊断困难,需尽早进行生化及遗传学检查,以早期诊断、争取治疗时间。饮食及营养干预是防治遗传代谢病的重要措施。不饱和脂肪酸是神经发育及功能维护中的重要营养素,通过常规饮食不能满足患儿对不饱和脂肪酸的需求,需要补充不饱和脂肪酸作为主要或辅助治疗方法。蛹油富含α-亚麻酸,可药食兼用。传统医学研究证明蛹油具有良好的营养保健和药用价值,具有抗炎、抗过敏、抗癌、降血糖、调节血脂、清除自由基、抗氧化、提高记忆力等多种功效。文章综述蛹油及α-亚麻酸的特点,从营养干预的角度为应用蛹油防治遗传代谢病提供参考。

Inherited metabolic disorders have complex clinical manifestations with high rate of disability and mortality.The symptoms of the patients are usually non-specific,which results in difficult diagnosis.Biochemical and genetic examination should be performed as early as possible to confirm the diagnosis and save time for treatment.Dietary and nutritional interventions are important measures for the prevention and treatment of inherited metabolic disorders.Unsaturated fatty acids are essential nutrients in neurodevelopment and functional maintenance.Conventional diets cannot provide enough unsaturated fatty acids for children.Supplementation of unsaturated fatty acids is necessary as a main or supportive treatment.Bombyx mori oil is rich inα-linolenic acid and can be used as medicine and food.Traditional medical research has proved that bombyx mori oil has good nutritional and medicinal value,having the effect of anti-inflammation,anti-allergy,anti-cancer,lowering blood sugar,regulating lipid,scavenging free radicals,antioxidation,and improving memory and other efficacy.This review summarizes the characteristics of bombyx mori oil andα-linolenic acid to provides reference for the application of bombyx mori oil in the treatment of inherited metabolic disorders from the perspective of nutritional intervention.