20%氧化锌硫软膏治疗面部蠕形螨病的临床疗效及安全性分析

Clinical Efficacy and Safety Analysis of 20%Zinc Oxide Sulfur Ointment for the Treatment of Facial Demodicidosis

目的观察20%氧化锌硫软膏治疗面部蠕形螨病的临床疗效并对其安全性进行分析评估。方法将80例面部蠕形螨病患者按照随机法分为实验组40例和对照组40例,实验组采用20%氧化锌硫软膏治疗,对照组采用甲硝唑凝胶治疗,分别于治疗第2周以及第4周时观察患者的临床疗效、安全性及满意度,并在治疗结束后3个月随访比较复发率。结果治疗2周后,实验组显效率(92.50%)高于对照组(72.50%),差异有统计学意义(P<0.05),4周治疗结束后,实验组的痊愈率(92.50%)高于对照组(67.50%),差异具备统计学研究意义(P<0.05)。实验组不良反应发生率(10.00%)高于对照组(2.50%),差异不具有统计学意义(P>0.05),且在加用医用保湿霜后不良反应均消失。实验组复发率(2.50%)低于对照组(7.50%),差异不具备统计学意义(P>0.05)。实验组满意度(90.00%)高于对照组(72.50%),差异有统计学意义(P<0.05)。结论在规范治疗的前提下,20%氧化锌硫软膏治疗面部蠕形螨病的有效率及治疗痊愈率较高,且皮损缓解快,满意度更高,值得临床应用。

Objectives To evaluate the clinical efficacy and safety of 20%zinc oxide sulfur ointment in the treatment of facial demodicidosis.Methods The 80 patients with facial demodicidosis were randomly divided into 40 cases in the experimental group and 40 cases in the control group,the experimental group was treated with 20%zinc oxide sulfur ointment and the control group was treated with metronidazole gel.To analyze and compare the clinical efficacy,safety and satisfaction rate of the two groups at the 2th week and the 4th week,and the recurrence rate was compared in the follow-up 3 months after the end of treatment.Results After 2 weeks of treatment,the experimental group(92.50%)showed a higher efficiency than the control group(72.50%),and the difference between the two groups was significant(P<0.05).After 4 weeks of treatment,the recovery rate of the experimental group(92.50%)was higher than that of the control group(67.50%),the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group(10.00%)was higher than the control group(2.50%),the difference was not statistically significant(P>0.05),and the adverse reactions disappeared after the addition of medical moisturizers.The recurrence rate in the experimental group(2.50%)was lower than the control group(7.50%),the difference was not statistically significant(P>0.05).The satisfaction rate of experimental group(90.00%)was higher than the control group(72.50%),and the difference was statistically significant(P<0.05).Conclusion Under the premise of standardized treatment,20%zinc oxide sulfur ointment has a higher efficiency and recovery rate in the treatment of facial demodex mites,the skin lesions relieve quicker and the satisfaction rate is higher,which made it suitable for clinical practice.