温热对免疫系统的影响及其在感染性皮肤病中的应用

Effect of Hyperthermia on the Immune System and its Application in Infectious Skin Diseases

温热对免疫系统的影响是多因素的,可通过热休克蛋白的产生与释放调节免疫,增强和调动免疫应答,进而达到治疗感染性皮肤病的目的。因其疗效与激光、冷冻等传统治疗方式相当,无明显疼痛、具有“远位”治疗作用、复发率低等优势,温热疗法广泛应用于病毒疣的治疗,且在孢子丝菌病、分枝杆菌等皮肤真菌与细菌性感染中亦展开应用。本文总结温热疗法对免疫系统的影响,及其在感染性皮肤病中的应用现状,并对温热疗法在皮肤科领域的应用进行展望。

Hyperthermia has a multifactorial effect on the immune system.It can regulate and enhance the immune response through heat shock protein production and release to achieve a cure for infectious skin diseases.Hyperthermia has already been widely applied in viral wart treatment because the efficacy is comparable to that of traditional medical treatments,such as laser or liquid nitrogen cryotherapy,with the advantages of less pain,a “remote” therapeutic effect,and a lower recurrence rate.Additionally,it is applied for skin fungal and bacterial infections,such as sporotrichosis and mycobacterium.The immunologic mechanism of hyperthermia and its application in the field of dermatology are reviewed,and the research trend in hyperthermia is also discussed in this article.