合成2-氯-5-氨基苯酚的新方法

A Novel Route for the Synthesize of 2-Chloro-5-aminophenol

报道了一种合成2-氯-5-氨基苯酚的新方法。以间氨苯酚为原料,在非质子极性溶剂乙腈和较低温度下,与N-氯代丁二酰亚胺反应制得2-氯-5-氨基苯酚。优化条件下,反应产物纯度达99.5%(HPLC),收率75%。

A novel route of synthesis for 2-chloro-5-aminophenol was reported.In a non-proton polar solvent with lower temperatures,NCS reacted with 3-aminophenol to obtain 2-chloro-5-aminophenol with a purity of99.5%(HPLC) and a yield of 75%.