百里醌的抗癌作用及其机制的研究进展

Research Progress on Anticancer Effect and Mechanism of Thymoquinone

百里醌(TQ)是从植物黑种草籽中提取的醌类化合物,在免疫调节、保肝、抗氧化、抗炎等方面具有广泛的生物学效应.研究发现, TQ对多种恶性肿瘤具有抑制效应,且毒副作用小,具有良好的临床前景.综述近年来TQ的药理作用研究进展,从药效学角度阐述TQ的抗癌作用及机制,为TQ的深入研究及临床应用提供参考.

Thymoquinone(TQ)is a quinone compound extracted from Nigella sativa.It has a wide range of biological effects in anti-inflammatory,immune regulation,liver protection,antioxidant and other aspects.Studies have found that TQ has inhibitory effect on a variety of malignant tumors with little toxic and side effects,which has a good clinical prospect.In this paper,we reviewed the pharmacological research progress of TQ in recent five years,and elaborated the anticancer effect and mechanism of TQ from the perspective of pharmacodynamics,so it can provide reference for the further research and clinical application of TQ.