动物乳汁“人源化”的研究进展

Research Arogress on“Humanization”of Animal Milk

动物乳腺生物反应器通过转基因技术将外源基因导入动物基因组中并定位表达于动物乳腺,进而利用动物乳腺天然、高效合成并分泌蛋白的能力,在动物乳汁中生产具有重要价值的产品,尤其是一些人源化蛋白。这项技术具有成本低、质量高、生物活性高、无污染、产量高等优点,开创了生物制药的新途径,发展前景广阔。本文主要对动物乳汁“人源化”在生物制药领域和改善乳成分方面的研究进展及应用前景进行综述和展望。

Animal mammary gland bioreactors use transgenic technology to introduce exogenous genes into animal genomes and locate and express them in animal mammary glands,and then utilize the ability of animal mammary glands to synthesize and secrete proteins naturally and efficiently to produce some valuable products in animal milk.This technology has the advantages of low cost,high quality,high biological activity,no pollution,and high yield.It has created a new way of biopharmaceuticals and has broad development prospects.In this paper,a brief review and prospect of the application research,technical method,future application prospects and challenges of animal milk“humanization”in the field of biopharmaceuticals and improving milk composition are made.