烟酰胺单核苷酸在中枢神经系统疾病中的作用研究进展

Recent advance in role of nicotinamide mononucleotide in central nervous system diseases

烟酰胺单核苷酸(NMN)是烟酰胺腺嘌呤二核苷酸(NAD^(+))转化的重要前体,其可通过提升机体内NAD^(+)水平,促进NAD^(+)在生物过程中的递氢作用,从而促进蛋白、多糖合成,提高物质转运和调控效率,改善代谢功能,尤其是在中枢神经系统疾病中,NMN可通过抗氧化、抗炎、线粒体保护、防止神经元及轴突变性等方式发挥神经保护作用。本文现围绕NMN在常见中枢神经系统疾病中发挥的治疗作用及其神经保护作用机制的研究进展进行综述,以期更深入理解NMN在中枢神经系统疾病中的作用,为预测中枢神经系统疾病治疗靶点、筛选治疗药物提供参考。

Nicotinamide mononucleotide(NMN)is an important precursor in conversing nicotinamide adenine dinucleotide(NAD^(+))in the body.By elevating NAD^(+)level in the body,NMN enhances the hydrogen transfer function of NAD^(+)in biological processes,promotes the synthesis of proteins and polysaccharides,improves substance transportation and regulatory efficiency,and enhances metabolic functions.Specifically,in central nervous system disease,NMN exerts neuroprotective effect through antioxidation,anti-inflammation,mitochondrial protection,and prevention of neuronal and axonal degeneration.This review focuses on the therapeutic role of NMN in common central nervous system diseases and their neuroprotective mechanisms,so as to further understand the role of NMN in central nervous system diseases,and provide references for predicting therapeutic targets and screening therapeutic drugs for central nervous system diseases.