垂体神经内分泌肿瘤患者的认知功能相关研究进展

Recent advance in cognitive function in patients with pituitary neuroendocrine tumors

垂体神经内分泌肿瘤(PitNETs)是全球范围内第二常见的中枢神经系统肿瘤,患者临床表现包括头痛、视力下降、视野缺损及认知功能障碍。认知功能是大脑获取、分析、处理外界信息的能力,一旦患者出现严重的认知功能障碍,给家庭及社会带来沉重的负担。本文从激素水平、垂体周围解剖结构、肿瘤体积、治疗、认知功能评估的角度,对PitNETs患者认知功能相关研究进展进行综述,以期为今后相关机制的阐明提供研究思路、为患者康复计划的制订提供依据。

Pituitary neuroendocrine tumors(PitNETs)are the second common central nervous system tumors.Patients often present with headache,vision loss,visual field defects,and cognitive dysfunction.Cognitive function is the ability of the brain to acquire,analyze and process external information;once the patient has serious cognitive dysfunction,it will bring heavy burden to the family and society.This article summarizes the cognitive functions in patients with PitNETs from perspectives of hormone,anatomical structures around the pituitary,tumor volume,treatment,and cognitive function assessment,in order to provide research ideas in elucidating relevant mechanisms in the future and provide basis for formulating rehabilitation plans for patients.