A型肉毒毒素在皮瓣移植中应用的研究进展

Research progress of botulinum toxin A in flap transplantation

A型肉毒毒素在医疗美容中有着广泛应用,如除皱、面部精细提升,以及改善面部、肩部、小腿轮廓等。近年来随着研究的深入,学者们发现A型肉毒毒素在改善皮瓣血运方面也存在着一定的作用。该文回顾了近年发表的相关文献,总结A型肉毒毒素在体内及体外实验中的应用进展,并分析其作用机制,如改善皮瓣灌注、减少血栓形成、促进血管新生、抑制炎症反应等。A型肉毒毒素的成功应用可为临床治疗提供一种更为简便、可靠的改善皮瓣血运的方法,对改善患者的预后、缩短住院时间、减少住院费用均有积极意义。

Botulinum toxin A is of extensive application in medical cosmetology,such as wrinkle removal,facial lift,and improving the contour of face,shoulder,calf and so on.Recent studies have found that botulinum toxin A also plays a certain role in improving the blood supply of flaps.This paper reviews the relevant articles published in recent years,summarizes the application of botulinum toxin A in vivo and in vitro.The potential mechanism,for example,improving flap perfusion,reducing thrombogenesis,promoting angiogenesis and inhibiting inflammatory response are also analyzed in the paper.The successful application of botulinum toxin A can provide a more convenient and reliable method to improve the blood supply of the flap for clinical treatment,and that will make efforts to improve the prognosis of patients,shorten the hospitalization time and reduce the hospitalization expenses.