盐酸西那卡塞联合活性维生素D治疗继发性甲状旁腺功能亢进的临床疗效观察

Clinical observation of sinakase hydrochloride combined with active vitamin D in the treatment of secondary hyperparathyroidism

目的 观察继发性甲状旁腺功能亢进(secondary hyperparathyroidism,SHPT)应用盐酸西那卡塞联合活性维生素D治疗的临床疗效。方法 回顾分析鄱阳县人民医院2019年5月—2021年1月收治的80例SHPT患者临床资料,按入院顺序分组,对照组(n=40例)采用活性维生素D治疗,观察组(n=40例)在对照组基础上联合盐酸西那卡塞治疗,对比2种治疗方法的差异性。结果 治疗后,观察组临床治疗总有效率(95.00%)高于对照组(72.50%)P(<0.05);观察组不良反应发生率(7.50%)与对照组(5.00%)对比,差异无统计学意义P(>0.05);2组血钙水平较治疗前均有所升高,且观察组高于对照组(P<0.05);2组甲状腺体积、血磷及全段甲状旁腺素(immunoreactive parathyroid hormone,iPTH)水平较治疗前均有所降低,且观察组低于对照组(P<0.05)。结论 SHPT应用盐酸西那卡塞联合活性维生素D治疗的临床疗效显著,可明显改善患者血钙、血磷及i PTH水平,减少甲状腺体积,且不良反应少,安全性高,值得临床应用。

Objective To observe the clinical efficacy of sinakase hydrochloride combined with active vitamin D in the treatment of secondary hyperparathyroidism(SHPT).Methods The clinical data of 80 patients with SHPT treated in our hospital from May 2019 to January 2021 were retrospectively analyzed.They were divided into groups according to the admission order.The control group(n=40)was treated with active vitamin D,on this basis,the observation group(n=40)was treated with sinakase hydrochloride,and the differences between the two treatment methods were compared.Results After treatment,the total clinical effective rate in the observation group(95.00%)was higher than that in the control group(72.50%)(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(7.50%)and the control group(5.00%)(P>0.05).The level of blood calcium in the observation group was higher than that in the control group(P<0.05).The thyroid volume,blood phosphorus and iPTH levels in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).Conclusion The clinical efficacy of SHPT treated with sinakase hydrochloride combined with active vitamin D is significant.It can significantly improve the levels of blood calcium,blood phosphorus and iPTH,reduce the volume of thyroid gland,have less adverse reactions and high safety.It is worthy of clinical application.