高压氧治疗脑梗死的临床进展

Clinical progress of hyperbaric oxygen in the treatment of cerebral infarction

脑梗死是对中老年人生命健康产生严重威胁的疾病之一,病理学主要表现为神经细胞的缺氧缺血损伤,具有危险系数高、发展速度快的特点。脑梗死患者在临床中通常采用溶栓、抗栓、稳定斑块等治疗方式,以此有效控制病灶,帮助患者尽早恢复身体健康。对于不符合以上适应证的患者,往往利用改善脑循环及代谢、神经保护剂等治疗方式。很多患者在接受治疗之后依旧存在神经功能缺损,生活质量明显降低,给社会和患者家庭带来了很大的负担。患者出现脑梗死之后,神经元损伤会因不同的缺血时间和再灌注状态存在一定差异,缺血时间越长,神经元损伤程度就越严重,再灌注会导致损伤程度加重,因此有效缓解脑缺氧缺血,控制脑水肿是改善脑梗死预后的重点。近些年来,高压氧治疗不断发展,在脑梗死的治疗上取得了明显的效果,并获得了越来越多学者和患者的认可与关注,已经成为了治疗脑梗死患者的主要方式之一。本文对高压氧治疗脑梗死的临床研究进展进行综述,以期对脑梗死的临床治疗提供参考方案。

Cerebral infarction is one of the diseases that pose a serious threat to the life and health of the middle-aged and elderly people.The pathology is mainly characterized by hypoxic-ischemic injury of nerve cells.It has the characteristics of high risk coefficient and rapid development.Patients with cerebral infarction usually use thrombolysis,antithrombotic,stable plaque and other treatment methods in clinic,so as to effectively control the focus and help patients recover their health as soon as possible.For the patients who do not meet the above indications,treatment methods such as improving cerebral circulation and metabolism and neuroprotective agents are often used.Many patients still have neurological deficits after treatment,and their quality of life has significantly reduced,which has brought great burden to the society and patients'families.After cerebral infarction of patients,there will be some differences in neuronal injury due to ischemia time and reperfusion state.The ischemia time is longer,the degree of neuronal injury will be more serious,and reperfusion will aggravate the degree of injury.Therefore,the key to improve the prognosis of cerebral infarction is to effectively alleviate cerebral hypoxia ischemia and control cerebral edema.In recent years,with the continuous development of hyperbaric oxygen therapy,it has achieved remarkable effects in the treatment of cerebral infarction,and has been recognized and concerned by more and more scholars and patients.It has become one of the main ways to treat patients with cerebral infarction.This paper reviews the clinical research progress of hyperbaric oxygen in the treatment of cerebral infarction,in order to provide reference scheme for the clinical treatment of cerebral infarction.