摘要
复发性流产是生殖医学领域常见的一种妊娠并发症,严重威胁女性身心健康;其病因及发病机制复杂,滋养细胞的凋亡、迁移、侵袭和胎盘血管生成、上皮间充质转化、免疫耐受和子宫内膜蜕膜化等因素参与了复发性流产的过程。磷脂酰肌醇-3激酶/蛋白激酶B(PI3K-AKT)信号通路参与各种细胞功能调节,在细胞生长、凋亡、血管生成和细胞的迁移、侵袭等方面发挥着重要作用。本文就近年来PI3K-AKT通路参与复发性流产的机制研究进展进行综述,并对今后的研究方向进行探讨及展望。
Recurrent spontaneous abortion is a common pregnancy complication in the field of reproductive medicine,which seriously threatens women's physical and mental health.Its etiology and pathogenesis are complex.The apoptosis,migration and invasion of trophoblasts,placental angiogenesis,epithelial-mesenchymal transformation,immune tolerance and endometrial decidualization and other factors participate in the process of recurrent abortion.Phosphatidylinositol-3 kinase(PI3K-AKT)signal pathway is involved in various cell function regulation and plays an important role in cell growth,apoptosis,angiogenesis,cell migration and invasion.In this paper,the mechanism of PI3K-AKT pathway involved in recurrent abortion in recent years is reviewed,and the future research directions are discussed and prospected.
作者
宋亚静
马玉聪
杜惠兰
SONG Ya-jing;MA Yu-cong;DU Hui-lan(Institute of Integrated Chinese and Western Medicine,Hebei University of Chinese Medicine,Shijiazhuang 050091,Hebei Province,China;Hebei Collaborative Innovation Centerfor Reproductive Diseases of Integrated Traditional Chinese and Western,Shijiazhuang 050091,Hebei Province,China;Hebei Key Laboratory of Liver and Kidney Diseases of Integrated Traditional Chinese and Western Medicine,Shjiazhuang 050091,Hebei Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2023年第19期2876-2880,共5页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(U21A20403)
河北中医学院博士科研基金项目(BSZ2022008)。
关键词
复发性流产
磷脂酰肌醇-3激酶/蛋白激酶B信号通路
免疫耐受
血管生成
蜕膜化
上皮间充质转化
侵袭
recurrent spontaneous abortion
phosphatidylinositol-3 kinasee-protein kinase B signal pathway
immune tolerance
angiogenesis
decidua
epithelial-mesenchymal transformation
invasion
