基于“瘀毒”理论探讨急性冠脉综合征铁过载机制的中医内涵

Discussion on TCM Connotation of Iron Overload Mechanism in Acute Coronary Syndrome Based on Theory of“Blood Stasis and Toxin”

急性冠脉综合征(ACS)为心血管系统常见急重症,越来越多学者认为铁过载是导致不稳定斑块形成及ACS发生的重要因素。中医学认为“瘀毒”是ACS病理基础,机体内铁过度沉积表现出的“毒”性及其加速ACS发生的机制符合“瘀毒”病机。本文基于“瘀毒”理论探讨ACS铁过载机制的中医内涵,从来源、病理表现、致病特点方面阐述铁过载与ACS“瘀”的相关性,从概念、病因、病变范围、致病特点、损伤性强方面阐述铁过载与ACS“毒”的相关性,为ACS理论研究及临床防治提供参考。

Acute coronary syndrome(ACS)is a common acute and severe disease of cardiovascular system.Recently,more and more scholars believe that iron overload is an important factor leading to the formation of unstable plaques and the occurrence of ACS.In TCM,“blood stasis and toxin”is considered to be the basis of ACS.The mechanism of iron overdeposition and“toxin”manifestations accorded with the pathogenesis of“blood stasis and toxin”.This article explored the TCM connotation of the mechanism of iron overload in ACS based on the theory of“blood stasis and toxin”,elaborated on the correlation between iron overload and ACS“blood stasis”from the perspectives of source,pathological manifestations,and pathogenic characteristics,explained the correlation between iron overload and ACS“toxin”from the perspectives of concept,etiology,lesion range,pathogenic characteristics,and strong injury,in order to guide the theoretical reserach and clinical prevention and treatment of ACS.