双相情感障碍住院患者发生自杀的影响因素分析

Analysis of influencing factors of suicide in inpatients with bipolar disorder

目的:分析双相情感障碍(BD)住院患者发生自杀的影响因素。方法:回顾性分析2014年1月至2017年12月首都医科大学附属北京安定医院收治的1671例BD住院患者的临床资料。统计住院BD住院患者发生自杀的情况,采用Logistic回归分析BD住院患者发生自杀的影响因素。结果:1671例BD住院患者发生自杀168例,占10.05%(168/1671),设为自杀组,其余设为非自杀组;自杀组年龄≥45岁、既往心血管疾病史、昏迷抽搐史、免疫系统疾病史、发病年龄≥25岁、病程≥1年、抑郁发作、混合发作、伴有精神病性症状占比均高于非自杀组,差异有统计学意义(P<0.05);经Logistic回归分析结果显示,昏迷抽搐史、免疫系统疾病史、病程≥1年、抑郁发作、混合发作、伴精神病性症状均为影响住院双相障碍患者发生自杀的危险因素(OR>1,P<0.05)。结论:昏迷抽搐史、免疫系统疾病史、病程≥1年、抑郁发作、混合发作、伴精神病性症状均为影响双相情感障碍住院患者发生自杀的危险因素。

Objective:To analyze influencing factors of suicide in inpatients with bipolar disorder(BD).Methods:The clinical data of 1671 inpatients with BD admitted to Beijing Anding hospital of capital medical university from January 2014 to December 2017 were retrospectively analyzed.The suicides in the BD inpatients were statistically analyzed.Logistic regression was used to analyze the influencing factors of suicide in the BD inpatients.Results:There were 168 cases of suicide in the 1671 BD inpatients,accounting for 10.05%(168/1671),which were set as suicide group,and the rest were set as non-suicide group.The proportions of the patients with age≥45 years old,history of cardiovascular disease,history of coma and convulsion,history of immune system disease,age of onset≥25 years old,course of disease≥1 year,depressive episode,mixed episode and combined psychotic symptoms in the suicide group were higher than those in the non-suicide group,and the differences were statistically significant(P<0.05).The Logistic regression analysis showed that history of coma and convulsions,history of immune system diseases,course of disease≥1 year,depressive episode,mixed episode,and combined psychiatric symptoms were all risk factors for suicide in the inpatients with bipolar disorder(OR>1,P<0.05).Conclusions:History of coma and convulsion,history of immune system disease,course of disease≥1 year,depressive episode,mixed episode and combined psychotic symptoms are the risk factors for suicide in the inpatients with bipolar disorder.