尤瑞克林联合阿托伐他汀和阿司匹林治疗急性脑梗死患者的效果

Effects of urinary kallidinogenase combined with Atorvastatin and Aspirin in treatment of patients with acute cerebral infarction

目的:观察尤瑞克林联合阿托伐他汀和阿司匹林治疗急性脑梗死(ACI)患者的效果。方法:选取2020年11月至2022年5月该院收治的105例ACI患者进行前瞻性研究,按照随机数字表法分为研究组53例与对照组52例。对照组给予阿司匹林肠溶片联合阿托伐他汀钙片治疗,研究组在对照组基础上增加注射用尤瑞克林治疗,比较两组治疗总有效率、脑血流动力学指标(大脑前动脉血流速度、外周阻力)水平、血管内皮功能指标[血清内皮素-1(ET-1)、内皮型一氧化氮合酶(eNOS)、基质细胞衍生因子-1(SDF-1)]水平、美国国立卫生研究院卒中量表(NIHSS)评分和Barthel指数(BI)评分。结果:研究组治疗总有效率为92.45%,明显高于对照组的71.15%,差异有统计学意义(P<0.05);治疗后,研究组大脑前动脉血流速度、血清eNOS水平、SDF-1水平和BI评分高于对照组,外周阻力、血清ET-1水平和NIHSS评分低于对照组,差异均有统计学意义(P<0.05)。结论:尤瑞克林联合阿托伐他汀和阿司匹林治疗ACI患者可提高治疗总有效率和BI评分,改善脑血流动力学指标和血管内皮功能指标水平,降低NIHSS评分,效果优于阿司匹林联合阿托伐他汀治疗。

Objective:To observe effects of urinary kallidinogenase combined with Atorvastatin and Aspirin in treatment of patients with acute cerebral infarction(ACI).Methods:A prospective study was conducted on 105 patients with ACI admitted to this hospital from November 2020 to May 2022.They were divided into study group(53 cases)and control group(52 cases)according to the random number table method.The control group was treated with Aspirin enteric-coated tablets combined with Atorvastatin calcium tablets,while the study group was treated with urinary kallidinogenase for injection on the basis of those of the control group.The total effective rate,the cerebral hemodynamic index levels(anterior cerebral artery blood flow velocity,peripheral resistance),the vascular endothelial function index levels[serum endothelin-1(ET-1),endothelial nitric oxide synthase(eNOS),stromal cell derived factor-1(SDF-1)],the National Institutes of Health stroke scale(NIHSS)score,and the Barthel Index(BI)score were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.45%,which was significantly higher than 71.15%in the control group,the difference was statistically significant(P<0.05).After the treatment,the blood flow velocity of anterior cerebral artery,the serum eNOS level,SDF-1 levels and the BI score in the study group were higher than those in the control group;the peripheral resistance level,the serum ET-1 level and the NIHSS score were lower than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:Urinary kallidinogenase combined with Atorvastatin and Aspirin in the treatment of the ACI patients can improve the total effective rate and BI score,improve the levels of cerebral hemodynamics and vascular endothelial function,and reduce the NIHSS scores.Moreover,it is superior to Aspirin combined with Atorvastatin treatment.