肺力咳合剂联合盐酸氨溴索治疗小儿支气管肺炎的效果

Effects of Feilike mixture Combined with Ambroxol hydrochloride in treatment of bronchial pneumonia in children

目的:探讨肺力咳合剂联合盐酸氨溴索治疗小儿支气管肺炎的效果。方法:选取2020年1月至2022年1月该院收治的80例支气管肺炎患儿进行前瞻性研究,按抛硬币法将其分为对照组和观察组各40例。两组入院后均接受常规对症处理,对照组采用盐酸氨溴索治疗,观察组在对照组基础上联合肺力咳合剂治疗,比较两组临床症状改善时间、住院时间、治疗前后炎性因子[细胞间黏附分子-1(ICAM-1)、白细胞介素-1β(IL-1β)和C反应蛋白(CRP)]水平、肺功能指标[呼气峰值流速(PEF)、第1秒用力呼气容积(FEV_(1))/用力肺活量(FVC)]水平、临床疗效和不良反应发生率。结果:观察组发热、咳嗽、咳痰、肺部啰音等临床症状改善时间和住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组ICAM-1、IL-1β和CRP水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组FEV_(1)/FVC、PEF水平均高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.00%(38/40),高于对照组的72.50%(29/40),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:肺力咳合剂联合盐酸氨溴索治疗小儿支气管肺炎可提高治疗总有效率和肺功能指标水平,缩短临床症状改善时间、住院时间,降低炎性因子水平,效果优于单纯盐酸氨溴索治疗。

Objective:To investigate effects of Feilike mixture Combined with Ambroxol hydrochloride in treatment of bronchial pneumonia in children.Methods:A prospective study was conducted on 80 children with bronchial pneumonia admitted to this hospital from January 2020 to January 2022.They were divided into control group and observation group according to the coin tossing method,40 cases in each.Both groups received routine symptomatic treatment after admission.The control group was treated with Ambroxol hydrochloride,while the observation group was treated with Feilike mixture on the basis of that of the control group.The improvement time of clinical symptoms,the hospitalization time,the levels of inflammatory factors[intercellular adhesion molecule-1(ICAM-1),interleukin-1β(IL-1β)and C-reactive protein(CRP)]and lung function indexes[peak expiratory flow(PEF),forced expiratory volume in one second(FEV_(1))/forced vital capacity(FVC)]before and after the treatment,the clinical efficacy,and the incidence of adverse reactions were compared between the two groups.Results:The improvement time of clinical symptoms such as fever,cough,sputum,pulmonary rales and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of ICAM-1,IL-1βand CRP in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After the treatment,the levels of FEV_(1)/FVC and PEF in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 95.00%(38/40),which was higher than 72.50%(29/40)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Feilike mixture combined with Ambroxol hydrochloride in the treatment of the children with bronchial pneumonia can improve the total effective rate of treatment and the levels of lung function indexes,shorten the improvement time of clinical symptoms,and the hospitalization time,and reduce the levels of inflammatory factors.Moreover,it is superior to single Ambroxol hydrochloride treatment.