血清MMP-9、E-选择素、SAA及CRP鉴别小儿肺炎感染类型的价值

The Value of Serum MMP-9,E-selectin,SAA and CRP in Identifying the Type of Pediatric Pneumonia Infection

目的:探讨血清基质金属蛋白酶-9(MMP-9)、E-选择素、血清淀粉样蛋白A(SAA)及C反应蛋白(CRP)鉴别小儿肺炎感染类型的价值。方法:选择2020年12月至2022年12月在甘肃省妇幼保健院诊治的肺炎患儿96例作为研究对象,在96例患儿中,病原体检测结果为病毒性感染的患儿66例(病毒组),细菌性感染的患儿30例(细菌组)。检测所有患儿的血清MMP-9、E-选择素、SAA、CRP水平,比较各指标在不同感染类型患儿中的差异,并采用受试者工作特征曲线(ROC)分析各指标的诊断价值。结果:与细菌组患儿相比,病毒组患儿的血清MMP-9、E-选择素、SAA、CRP水平均明显更高,差异具有统计学意义(P<0.05)。ROC曲线结果显示,血清MMP-9、E-选择素、SAA、CRP鉴别小儿肺炎感染类型的的曲线下面积(AUC)分别为0.727、0.715、0.678、0.669。结论:小儿肺炎感染类型以病毒性感染为主,且病毒性感染肺炎患儿多伴随有血清MMP-9、E-选择素、SAA、CRP的水平升高。血清MMP-9、E-选择素、SAA、CRP对小儿肺炎感染类型的鉴别价值均较高。

Objective To investigate the value of serum matrix metalloproteinase-9(MMP-9),E-selectin,serum amyloid A(SAA)and C-reactive protein(CRP)in identifying the type of pediatric pneumonia infection.Methods From December 2020 to December 2022,96 children with pneumonia diagnosed and treated in Gansu Provincial Maternal and Child Health Care Hospital were selected as the study subjects,among the 96 children,the pathogen detection results were viral infection in 66 cases(virus group),and there were 30 children with bacterial infection(bacterial group).And the serum MMP-9,E-selectin,SAA,and CRP levels of all children were detected to compare the differences of each index in children with different types of infections,and the diagnostic value of each index was analyzed by using the receiver operating characteristic curve(ROC).Results Compared with the bacterial group,the levels of serum MMP-9,E-selectin,SAA and CRP in the viral group were significantly higher,with statistical significance(P<0.05).ROC curve results showed that the area under the curve(AUC)of serum MMP-9,E-selectin,SAA and CRP were 0.727,0.715,0.678 and 0.669,respectively.Conclusion The types of pediatric pneumonia infections are mainly viral infections,and viral infections in children with pneumonia are often accompanied by elevated levels of serum MMP-9,E-selectin,SAA,and CRP.Serum MMP-9,E-selectin,SAA,and CRP all have a high discriminatory value for pediatric pneumonia infection types.