异丙托溴铵联合布地奈德对小儿支气管哮喘并过敏性鼻炎的疗效

Efficacy of Ipratropium Bromide and Budesonide in Pediatric Children with Bronchial Asthma and Allergic Rhinitis

目的:观察异丙托溴铵联合布地奈德治疗干预对支气管哮喘并过敏性鼻炎患儿的临床效果。方法:选取郑州大学第五附属医院2021年1月至2022年12月收治的100例支气管哮喘并过敏性鼻炎患儿作为研究对象,以随机数字表法分为观察组和对照组,各50例。观察组患儿采用异丙托溴铵联合布地奈德治疗的干预措施,对照组患儿给予布地奈德治疗干预。治疗干预后,比较两组患儿临床疗效、炎症因子水平、T淋巴细胞亚群水平、肺功能、生活质量。结果:观察组患儿临床总有效率高于对照组,差异具有统计学意义(P<0.05)。观察组患儿血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平低于对照组,差异具有统计学意义(P<0.05)。观察组患儿外周血CD3^(+)、CD4^(+)水平高于对照组,CD8^(+)水平低于对照组,差异具有统计学意义(P<0.05)。观察组患儿第1秒用力呼气量(FEV1)、用力肺活量(FVC)、第1秒用力呼气量占用力肺活量比值(FEV1/FVC)高于对照组,差异具有统计学意义(P<0.05)。结论:异丙托溴铵联合布地奈德用于临床小儿支气管哮喘并过敏性鼻炎治疗中,患儿的临床症状不仅能得到较好改善,其肺功能水平还能得到提高。

Objective To observe the clinical effect of ipratropium bromide and budesonide in children with bronchial asthma and allergic rhinitis.Methods 100 children with bronchial asthma and allergic rhinitis admitted to the Fifth Affiliated Hospital of Zhengzhou University from January 2021 to December 2022 were selected as the research subjects,and they were divided into an observation group and a control group.Children in the observation group were treated with ipratropium bromide,and children in the control group were given budesonide with 50 cases in each group.After treatment intervention,the clinical efficacy,inflammatory factor level,T lymphocyte subset level,lung function,and quality of life were compared between the two groups.Results The clinical efficacy rate of the children in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The levels of serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),and hypersensitive C-reactive protein(hs-CRP)of the children in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CD3^(+)and CD4^(+)of the children in the observation group were higher than those in the control group,and the levels of CD8^(+)was lower than that in the control group,and the differences were statistically significant(P<0.05).Forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and forced expiratory volume in one second/forced vital capacity(FEV1/FVC)in the observation group of the children were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The treatment of ipratropium bromide and budesonide is used in clinical treatment of pediatric bronchial asthma and allergic rhinitis,and the effect is good.The clinical symptoms of children can not only be improved,but also improve the lung function level of children.