浙江省金华市金东区社区老年人肌少症前期与认知障碍的相关性研究

Correlation study between pre-sarcopenia and cognitive impairment in the elderly incommunitiy of Jindong District,Jinhua City,Zhejiang Province

目的 研究社区老年人肌少症前期与认知障碍的相关性。方法 2022年1月1日至7月30日对浙江省金华市金东区142例社区老年人进行调查,采用握力值和简易躯体功能评估筛查肌少症前期状态,采用简易精神状态检查(MMSE)进行认知功能筛查。比较认知障碍(认知障碍组,46例)和非认知障碍(非认知障碍组,96例)患者肌少症前期指标的差异,比较肌少症前期(肌少症前期组,71例)和非肌少症前期(非肌少症前期组,71例)患者MMSE评分的差异,并进行认知障碍影响因素的多因素分析。结果 认知障碍组患者三姿平衡、步速、椅上坐-站测试得分均明显低于非认知障碍组,握力值减低的比例、肌少症前期的比例均明显高于非认知障碍组,差异均有统计学意义(P<0.05);肌少症前期组患者MMSE总分,以及定向力、记忆力、注意力、回忆能力、语言能力亚领域得分均明显低于非肌少症前期组,差异均有统计学意义(P<0.05)。调整年龄之后的logistic回归模型分析显示,握力值减低、步速减慢将增加认知障碍的发生风险(优势比=3.457、0.516,95%可信区间:1.196~9.995、0.273~0.974)。结论 社区老年人肌少症前期与认知障碍显著相关。

Objective To investigate the correlation between pre-sarcopenia and cognitive disorder in the elderly in the communitiy.Methods From January 1 to July 30,2022,a total of 142 elderly people in jindong district,Jinhua City,Zhejiang Province were investigated.The grip strength and Short Physical Performance Battery were used to screen the pre-sarcopenia state,and mini-mental state examination(MMSE)was used to screen the cognitive function.The differences in pre-sarcopenia indexes between patients with cognitive impairment(the cognitive impairment group,46 cases)and non-cognitive impairment(the non-cognitive impairment group,96 cases)were compared.The differences in MMSE scores between patients with pre-sarcopenia(the pre-sarcopenia group,71 cases)and non-pre-sarcopenia(the non-pre-sarcopenia group,71 cases)were compared,and multivariate analysis of the influencing factors of cognitive impairment was performed.Results The scores of three-posture balance,stride speed and chair sit-stand test in the cognitive impairment group were lower than those in the non-cognitive impairment group,and the proportion of decreased grip strength and the proportion of early sarcopenia were significantly higher than those in the non-cognitive dysfunctiont group,with statistically significant differences(P<0.05).The MMSE total score,sub-domain scores of orientation,memory,attention,recall and language ability of patients in the pre-sarcopenia group were significantly lower than those in the non-sarcopenia group,and the differences were statistically significant(P<0.05).Logistic regression model analysis after age adjustment showed that decreasing grip strength and slowing pace would increase the risk of cognitive impairment(OR:3.457,0.516;95%CI:1.196-9.995,0.273-0.974).Conclusion There is a significant correlation between pre-sarcopenia and cognitive impairment in community elderly.