肾脏孤立性纤维性肿瘤伴广泛黏液变性1例报道并文献复习

Solitary fibrous tumor of the kidney with extensive muxoid change:a case report with review of literatures

目的 探讨肾脏孤立性纤维性肿瘤伴广泛黏液变性患者的临床病理特征、诊断及鉴别诊断。方法 2016年10月该院收治肾脏孤立性纤维性肿瘤伴广泛黏液变性患者1例,回顾性分析其临床及病理资料,并结合文献复习进行讨论。结果 患者,男,年龄21岁,术后随访5年无复发。肿瘤大小16 cm×10 cm×7 cm,分叶状;组织学观察见细胞密集区和疏松区交替分布伴广泛黏液变性。免疫组织化学检查CD34、CD99、SMA、Vimentin阳性,STAT6灶性阳性,CKpan、CK8/18、S-100、Desmin、HMB45、CDK4、MDM2阴性,Ki-67<10%阳性。结论 该肿瘤临床上较少见,经病理组织学及免疫组织化学检查确诊,需与多种疾病鉴别。

Objective To study the clinicopathological features,diagnosis and differential diagnosis of solitary fibrous tumor(SFT)of the kidney with extensive muxoid change.Methods In October 2016,A patient with kidney SFT with extensive myxosis was admitted to this hospital.The clinical and pathological data were retrospectively analyzed and discussed in combination with literature review.Results The patient,a 21-year-old male,was followed up for five years without recurrence.The tumor was 16 cm×10 cm×7 cm in size,lobulated shape.Histologically,the tumor cells were distributed in dense and sparse regions with extensive muxoid change.Immunohistochemically,the tumors were positive for CD34,CD99,SMA,Vimentin and focally positive for STAT6,but negative for CKpan,CK8/18,S-100,Desmin,HMB45,CDK4 and MDM2,and Ki-67<10%positive.Conclusion SFT was rare in clinic,whose diagnosis relying on histopathology and immunochemistry.The tumor should be differentiated from other diseases.