IL-37通过调控巨噬细胞极化抑制炎性疾病研究进展

Progress of IL-37 inhibiting inflammatory diseases by regulating macrophage polarization

白细胞介素-37(IL-37)是IL-1家族成员,在炎症进展过程中具有控制过度炎症和免疫的作用,从而保护或减轻组织损伤。巨噬细胞是先天免疫系统中的关键细胞成分,在局部微环境的作用下可活化为促炎的M1型和抗炎的M2型,参与炎症过程。随着近年来研究的深入,IL-37通过抑制M1型极化或促进M2型极化,从而在多种炎性疾病中对抗过度炎症的作用被越来越多的提及。该文主要概述了IL-37的抗炎机制及巨噬细胞极化,并重点讨论了IL-37通过调控巨噬细胞极化在多种炎性疾病中的作用及其在炎性疾病中的治疗价值。

Interleukin(IL)-37 is a member of the IL-1 family,which can control excessive inflammation and immunity during the progression of inflammation,thus protecting or mitigating tissue damage.Macrophages are the key cellular components in the innate immune system.Under the action of local microenvironment,macrophages can be activated into pro-inflammatory M1 type and anti-inflammatory M2 type to participate in the inflammatory process.With the deepening of research in recent years,the role of IL-37 in combating excessive inflammation in a variety of inflammatory diseases by inhibiting M1 macrophage polarization or promoting M2 macrophage polarization has been mentioned more and more.This paper mainly reviewed the anti-inflammatory mechanism and macrophage polarization of IL-37,and focused on the role of IL-37 in various inflammatory diseases by regulating macrophage polarization,and its therapeutic value in inflammatory diseases.