线粒体参与铁死亡的研究进展

Research progress of mitochondria involved in ferroptosis

线粒体是真核生物细胞重要的细胞器之一,参与了多种生理活动。铁死亡是一种铁依赖的新型细胞程序性死亡,以铁超载、抗氧化系统失衡、脂质过氧化为主要特征。线粒体参与多种形式的细胞死亡,深入了解线粒体在铁死亡中的作用对细胞生物学和临床疾病治疗具有重要意义。该文从线粒体三羧酸循环及氧化磷酸化、线粒体自噬、线粒体DNA等不同层面探讨了其在铁死亡发生中的作用,为基于线粒体开展铁死亡相关疾病防治提供理论依据。

Mitochondria is one of the important organelles in eukaryotic cells,participating in various physiological activities.Ferroptosis is a new iron-dependent programmed cell death,which is characterized by iron overload,antioxidant system imbalance and lipid peroxidation.Mitochondria are involved in various forms of cell death.It is of great significance to understand the role of mitochondria in ferroptosis for cell biology and clinical disease treatment.In this paper,the role of mitochondrial tricarboxylic acid cycle,oxidative phosphorylation,mitochondrial mitophagy,mitochondrial DNA and other aspects in the occurrence of ferroptosis was discussed,which provided theoretical basis for the prevention and treatment of ferroptosis-related diseases based on mitochondria.