肠道菌群及粪便代谢物与过敏性鼻炎的关系

Relationship between intestinal flora and fecal metabolites and allergic rhinitis

过敏性鼻炎(AR)作为一种反复发作的过敏性炎症疾病,在我国的发病率逐年增加,严重影响了患者的工作和生活。但目前AR的发病机制尚不清晰。有研究发现,肠道菌群及粪便代谢物不仅能相互作用,且二者均能通过影响黏膜屏障功能、调节免疫等方式参与AR的发生、发展,为AR的治疗提供了新的可能性。该文对近年来研究肠道菌群及相关粪便代谢物与AR关系的文章进行了综述,旨在为AR的治疗和发病机制的研究提供思路。

Allergic rhinitis(AR),as a recurrent allergic inflammatory disease,has an increasing incidence year by year in China,which seriously affects the work and life of patients.However,the pathogenesis of AR is still unclear,and the studies have found that intestinal flora and fecal metabolites can not only interact with each other,but both can participate in the occurrence and development of AR by affecting mucosal barrier function,regulating immunity,and so on,which may provide new possibilities for the treatment of AR.This paper reviewed the articles on the relationship between intestinal flora and related fecal metabolites and AR in recent years,in order to provide ideas for the treatment and pathogenesis of AR.