绝经后女性甲状腺功能亢进与骨密度的相关性分析

Correlation Analysis of Hyperthyroidism and Bone Mineral Density in Postmenopausal Women

目的:探讨绝经后女性甲状腺功能亢进与各部位骨密度的相关性。方法:选取2021年10月至2022年4月在云南省第一人民医院就诊的220例绝经后女性作为研究对象,比较所有受试者的骨密度值和甲状腺功能指标水平,并按病程长短将甲状腺功能亢进症患者分成不同亚组,比较亚组间骨密度值测量情况。结果:甲状腺功能亢进症患者腰椎、股骨颈、Wards三角、大粗隆、全身的骨密度值显著低于非甲状腺功能亢进症者,病程≥1年的甲状腺功能亢进症患者腰椎骨密度值显著低于病程<1年者(P<0.05);游离三碘甲状腺原氨酸(FT3)水平与股骨颈、Wards三角和全身骨密度值呈负相关,游离甲状腺素(FT4)水平与Wards三角骨密度值呈负相关。结论:绝经后甲状腺功能亢进女性的骨密度值显著低于绝经后非甲状腺功能亢进女性,病程延长更容易导致腰椎骨密度值下降,FT3、FT4水平与骨密度值呈负相关。

Objective:To explore the correlation between hyperthyroidism and bone mineral density(BMD)in postmenopausal women.Methods:A total of 220 postmenopausal women who visited the First People's Hospital of Yunnan Province from October 2021 to April 2022 were selected as the study subjects.BMD and thyroid function indicators were compared among all participants.The patients with hyperthyroidism were divided into different subgroups according to the duration of the disease,and BMD measurements were compared among the subgroups.Results:The BMD values of lumbar vertebra,neck of femur,Wards triangle,greater trochanter and the whole body in patients with hyperthyroidism were significantly lower than in those without hyperthyroidism.Among patients with hyperthyroidism,those with a disease duration of≥1 year had significantly lower BMD values in the lumbar spine compared to those with a disease duration of<1 year(P<0.05).The levels of free triiodothyronine(FT3)were negatively correlated with BMD values in the neck of femur,Wards triangle,and the whole body,while the levels of free thyroxine(FT4)were negatively correlated with BMD values in Wards triangle.Conclusion:The BMD values of postmenopausal women with hyperthy-roidism are significantly lower than those without hyperthyroidism.Prolonged disease duration is more likely to lead to a decrease in lumbar spine BMD.FT3 and FT4 levels are negatively correlated with BMD values.