HMGB1-TLR4/RAGE信号通路在呼吸机相关性肺炎中的研究进展

Research progress of HMGB1-TLR4/RAGE signaling pathway in ventilator-associated pneumonia

呼吸机相关性肺炎(VAP)是一种医源性肺部感染,其发病机制复杂,缺乏诊断标志物和治疗靶点。高迁移率蛋白1(HMGB1)主要在真核细胞内表达,当细胞坏死后被动释放,晚期糖基化终末产物受体(RAGE)和Toll样受体(TLR)是HMGB1的主要受体,介导炎症因子的释放。目前针对呼吸机肺功能损害发生发展机制的研究较少,现对HMGB1参与呼吸机相关性肺炎的发病机制进行阐述,以期进一步为呼吸机相关性肺炎提供一种新的研究思路。

Objective Ventilator-associated pneumonia(VAP)is an iatrogenic lung infection with a complex pathogenesis,and there is still a lack of diagnostic markers and therapeutic targets.High mobility group protein B1(HMGB1)is mainly expressed in eukaryotic cells,which is passively released when the cells are necrotic.The Receptor of the advanced glycosylation end product(RAGE)and Toll-like receptor(TLR)are the main receptors for HMGB1,which works to mediate the release of inflammatory factors.At present,there are few studies on the pathogenesis of ventilator pulmonary impairment.This review elaborates HMGB1 as a mechanism involved in the pathogenesis of ventilator-associated pneumonia,with the aim of further providing a new research idea for ventilator-associated pneumonia.