量化评估策略下综合疼痛干预对宫颈癌根治术后患者疼痛及应激反应的影响

Effect of comprehensive pain intervention under quantitative evaluation strategy on postoperative pain and stress response of patients undergoing radical resection of cervical cancer

目的探讨量化评估策略下综合疼痛干预对宫颈癌根治术后患者疼痛及应激反应的影响。方法根据干预方式的不同将102例宫颈癌根治术患者分为对照组和观察组,每组51例,对照组患者采取常规围手术期干预,观察组患者在对照组的基础上给予量化评估策略下综合疼痛干预。比较两组患者的疼痛程度[视觉模拟评分法(VAS)]、疼痛相关指标[一氧化氮(NO)、前列腺素E2(PGE2)及P物质(SP)]、应激反应指标[去甲肾上腺素(NE)、皮质醇(Cor)及促肾上腺皮质激素(ACTH)]。结果术后8、24、48 h,观察组患者的VAS评分均明显低于对照组,差异均有统计学意义(P﹤0.01)。术后24、48 h,观察组患者的NO、PGE2、SP、NE、Cor、ACTH水平均低于对照组,差异均有统计学意义(P﹤0.05)。结论对宫颈癌根治术患者实施量化评估策略下综合疼痛干预效果良好,可有效减轻术后疼痛和应激反应。

Objective To explore the effect of comprehensive pain intervention under quantitative evaluation strategy on postoperative pain and stress response of patients undergoing radical resection of cervical cancer.Method A total of 102 patients undergoing radical resection of cervical cancer were divided into the control group(n=51,received routine perioperative intervention)and the observation group(n=51,received comprehensive pain intervention under the quantitative evaluation strategy on the basis of control group)according to different intervention methods.The pain degree[visual analogue scale(VAS)],pain related indicators[nitric oxide(NO),prostaglandin E2(PGE2)and substance P(SP)],stress response indicators[norepinephrine(NE),cortisol(Cor)and adrenocorticotropic hormone(ACTH)]were compared between the two groups.Result Eight,twenty-four,and forty-eight hours after surgery,the VAS scores in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.01).Twenty-four and forty-eight hours after surgery,the levels of NO,PGE2,SP,NE,Cor and ACTH in the observation were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The effect of comprehensive pain intervention under the quantitative evaluation strategy is significant for patients undergoing radical resection of cervical cancer,which can reduce the postoperative pain and stress response of patients.