2020年版中国药典中治疗原发性肝癌的中成药用药特点

Prescription characteristics of Chinese patent medicine for the treatment of primary liver cancer in Chinese Pharmacopoeia(2020 Edition)

目的探讨2020年版中国药典中治疗原发性肝癌的中成药的用药特点,为临床使用中成药治疗原发性肝癌提供参考依据。方法收集2020年版中国药典中治疗原发性肝癌的中成药并进行分类,应用频数法对其用药特点进行统计分析。结果2020年版中国药典中治疗原发性肝癌的中成药共92种,以补益剂、清热剂、理血剂为主;具有治疗作用的中成药44种,辅助治疗作用的27种,药理研究具有抗肝细胞癌作用的21种;益气药、化瘀消癥药、清热解毒药在中成药中使用最多,使用频数最多的药物为黄芪、人参、当归、莪术、半枝莲、白花蛇舌草、大黄、郁金、丹参、鳖甲、蟾蜍、茯苓、甘草、女贞子;药性以温、寒、平为主;药味以苦、甘、辛为主;药物归经以五脏为主。结论治疗原发性肝癌的中成药以补益剂、清热剂和理血剂为主,具有一定的规律和特点,临床中应当遵循辨证论治规范合理选择中成药。

Objective To explore the prescription characteristics of Chinese patent medicine in the treatment of primary liver cancer(PLC)in Chinese Pharmacopoeia(2020 Edition),and to provide reference for the clinical use of Chinese patent medicine in the treatment of PLC.Method The Chinese patent medicines for the treatment of PLC in Chinese Pharmacopoeia(2020 Edition)were collected,classified and statistically analyzed by frequency method.Result There were 92 kinds of Chinese patent medicines for PLC in Chinese Pharmacopoeia(2020 Edition),mainly the supplementing agents,heat-clearing agents and blood-removing agents.There were 44 kinds of Chinese patent medicines with therapeutic effect,27 kinds with adjuvant therapeutic effect and 21 kinds with anti-hepatocellular carcinoma effect in pharmacological research.Nourishing Qi medicine,dissolving blood-stasis medicine and clearing heat and detoxication medicine were most widely used in prescriptions.Astragalus,ginseng,angelica,curcumae rhizoma,scutellariabarbata,hedyotis diffusa,curcumae radix,salvia miltiorrhiza,salvia,trionycis carapax,toad,tuckahoe,licorice,and fructus ligustri lucidi were used most commonly used TCM.The drug was mainly warm,cold,and flat.The taste of the drug was mainly bitter,sweet,and pungent.Drug meridian is mainly on five viscera.Conclusion Chinese patent medicines for the treatment of PLC are mainly composed of supplementing agents,heat-clearing agents and blood-removing agents,which have certain regularities and characteristics.In clinical practice,Chinese medicines should be reasonably selected according to the rules of syndrome differentiation.