红细胞分布宽度(RDW)可作为肝癌的一个预后指标:Meta分析

Red Cell Distribution Width as a Prognostic Factor for Liver Cancer:a Meta Analysis

目的:总结红细胞分布宽度(RDW)对肝癌患者的预后影响。方法:利用拟定的检索词检索Pubmed,Embase,EBSCO,万方等数据库的中英文文献中提取出RDW与总生存期、中位生存期及无瘤生存期等相关性数据进行Meta分析。结果:共有8篇文章纳入研究中,包含10项研究共2196例患者。Meta分析结果提示在肝癌患者中RDW与总生存期呈负相关(HR:1.73,95%CI:1.44-2.07,P<0.00001);在中位生存期与无瘤生存期中RDW宽度为肝癌患者的不良预后因素。结论:RDW可作为肝癌预后的一项指标。

Objective:To summarize the effect of red cell distribution width(RDW)on the prognosis of patients with liver cancer.Methods:Searching the database of Pubmed,Embase,EBSCO,Wanfang and so on,and get the applicable Chinese and English thesis.The correlation data of RDW with overall survival time(OS),median survival time and disease-free survival time(DFS)were extracted and analyzed by Meta analysis.Results:A total of 8 articles were included,including 10 studies involving 2,196 patients.The results of Meta analysis showed that the RDW was negatively correlated with the OS in Liver cancer patients.In addition,the RDW was also suggested as a prognostic factor in patients with Liver cancer during median survival time and disease-free survival time(DFS).Conclusion:RDW can be used as a prognostic marker for liver cancer.