依达拉奉辅助阿司匹林治疗急性脑梗死的临床疗效

Clinical Effect of Edaravone in the Treatment of Acute Cerebral Infarction with Aspirin

目的:研究依达拉奉辅助阿司匹林治疗急性脑梗死的临床疗效。方法:选取于许昌市中心医院2019年1月至2021年1月就诊的63例急性脑梗死患者,以随机数法将其分为对照组31例及观察组32例。两组患者均给予抗凝、溶栓等常规治疗,对照组在常规治疗基础上加用阿司匹林肠溶片,观察组在对照组基础上加用依达拉奉治疗。比较两组患者疗效、治疗前及治疗2周后神经血管损伤标志物[同型半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(S100–β)]、炎症因子[C反应蛋白(CRP)、白细胞介素–6(IL–6)、肿瘤坏死因子–α(TNF–α)]水平以及药物不良反应发生状况。结果:观察组患者总有效率为93.75%,高于对照组的70.97%,差异具有统计学意义(P<0.05);治疗后,观察组患者的Hcy、S100–β、NSE、CRP、IL–6、TNF–α水平均低于对照组,差异具有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:采用依达拉奉联合阿司匹林治疗急性脑梗死患者,可以改善患者神经血管受损情况,减轻炎症反应,不良反应发生率低,具有较高的安全性。

Objective To study the clinical effect of edaravone in the treatment of acute cerebral infarction with aspirin.Methods 63 patients with acute cerebral infarction treated in Xuchang Central Hospital from January 2019 to January 2021 were selected and divided into a control group(31 cases)and an observation group(32 cases)by random number method.Both groups were given conventional treatment such as anticoagulation and thrombolysis,the control group was given aspirin enteric-coated tablet on the basis of conventional treatment,and the observation group was given edaravone on the basis of the control group.The efficacy,neurovascular injury markers[homocysteine(Hcy),neurone specific enolase(NSE),central nervous system specific proteinβ[(S100-β)],inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)],tumor necrosis factor-α(TNF-α)before treatment and 2 weeks after treatment were compared between the two groups and the occurrence of adverse drug reactions.Results The total effective rate of the observation group was 93.75%,higher than that of the control group(70.97%),the difference was statistically significant(P<0.05).After treatment,the levels of Hcy,S100-β,NSE,CRP,IL-6 and TNF-αin the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Edaravone combined with aspirin was used to treat patients with acute cerebral infarction,it can improve the damage of nerve blood vessels in patients,reduce inflammatory response,low incidence of adverse reactions,and high safety.